Oxygen-enhanced MRI for patients with connective tissue diseases: comparison with thin-section CT of capability for pulmonary functional and disease severity assessment

European Journal of Radiology
Yoshiharu OhnoKazuro Sugimura

Abstract

To prospectively and directly compare oxygen-enhanced (O2-enhanced) MRI with thin-section CT for pulmonary functional loss and disease severity assessment in connective tissue disease (CTD) patients with interstitial lung disease (ILD). Thin-section CT, O2-enhanced MRI, pulmonary function test and serum KL-6 were administered to 36 CTD patients with ILD (23 men, 13 women; mean age: 63.9 years) and nine CTD patients without ILD (six men, and three women; mean age: 62.0 years). A relative-enhancement ratio (RER) map was generated from O2-enhanced MRI and mean relative enhancement ratio (MRER) for each subject was calculated from all ROI measurements. CT-assessed disease severity was evaluated with a visual scoring system from each of the thin-section CT data. MRER and CT-assessed disease severities of CTD patients with and without ILD were then statistically compared. To assess capability for pulmonary functional loss and disease severity assessment in CTD patients, correlations of MRER and CT-assessed disease severity with pulmonary functional parameters and serum KL-6 in all subjects were statistically determined. MRER and CT-assessed disease severity showed significant differences between CTD patients with (MRER: 0.15 ± 0.08, ...Continue Reading

References

Nov 1, 1987·The American Review of Respiratory Disease·A S Buist
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·Y HondaS Abe
Oct 14, 1998·American Journal of Respiratory and Critical Care Medicine·T TakahashiY Kawakami
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·A YokoyamaK Hiwada
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·H TakahashiS Abe
Oct 9, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M SalernoJ P Mugler
Nov 9, 2001·Radiologic Clinics of North America·T Franquet
Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yoshiharu OhnoKazuro Sugimura
May 29, 2004·Radiology·Nobuyuki TanakaDavid A Lynch
Nov 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bastiaan DriehuysG Allan Johnson
Jun 3, 2011·European Respiratory Review : an Official Journal of the European Respiratory Society·D Valeyre
Sep 17, 2013·American Journal of Respiratory and Critical Care Medicine·William D TravisUNKNOWN ATS/ERS Committee on Idiopathic Interstitial Pneumonias
Feb 5, 2015·European Journal of Radiology·Maarten K NinaberBerend C Stoel

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Citations

Apr 25, 2016·Clinical Rheumatology·Iago Pinal-FernandezMiquel Vilardell-Tarres
Oct 21, 2015·Current Rheumatology Reports·Yoshiharu OhnoShinichiro Seki
Mar 20, 2019·Thorax·Nicholas D WeatherleyJim M Wild
Feb 3, 2021·The British Journal of Radiology·Yoshiharu OhnoHiroshi Toyama
Apr 7, 2018·Radiologic Clinics of North America·Mario CilibertoYoshiharu Ohno
May 7, 2021·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Yumi TanakaHiroshi Toyama
Jul 20, 2019·Respiratory Medicine·Lilian LonzettiBruno Hochhegger

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