Oxygen extraction fraction mapping at 3 Tesla using an artificial neural network: A feasibility study

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Sebastian DomschLothar R Schad

Abstract

The oxygen extraction fraction (OEF) is an important biomarker for tissue-viability. MRI enables noninvasive estimation of the OEF based on the blood-oxygenation-level-dependent (BOLD) effect. Quantitative OEF-mapping is commonly applied using least-squares regression (LSR) to an analytical tissue model. However, the LSR method has not yet become clinically established due to the necessity for long acquisition times. Artificial neural networks (ANNs) recently have received increasing interest for robust curve-fitting and might pose an alternative to the conventional LSR method for reduced acquisition times. This study presents in vivo OEF mapping results using the conventional LSR and the proposed ANN method. In vivo data of five healthy volunteers and one patient with a primary brain tumor were acquired at 3T using a gradient-echo sampled spin-echo (GESSE) sequence. The ANN was trained with simulated BOLD data. In healthy subjects, the mean OEF was 36 ± 2% (LSR) and 40 ± 1% (ANN). The OEF variance within subjects was reduced from 8% to 6% using the ANN method. In the patient, both methods revealed a distinct OEF hotspot in the tumor area, whereas ANN showed less apparent artifacts in surrounding tissue. In clinical scan times,...Continue Reading

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Citations

Dec 11, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Felix GlangMoritz Zaiss
Jul 6, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Simon HubertusLothar Rudi Schad
Jul 21, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Soozy JungDong-Hyun Kim
Aug 9, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Max ToropUlugbek S Kamilov
Nov 6, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marcelo V W ZibettiRavinder R Regatte

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