PMID: 2116777Aug 1, 1990Paper

Oxygen free radical scavengers decrease reperfusion injury in lung transplantation

The Annals of Thoracic Surgery
F C DetterbeckB R Wilcox

Abstract

An in vivo canine model was used to assess the ability of an oxygen free radical scavenger to decrease reperfusion injury in lung transplantation. In 12 dogs, the left lungs were transplanted after they had been preserved for 24 hours at 4 degrees C after pulmonary artery flushing with modified Eurocollins solution. In 6 dogs, dimethylthiourea, a potent oxygen free radical scavenger, was added to the flush solution and was also given to the recipients just before reperfusion. In all animals, the contralateral pulmonary artery and bronchus were ligated and lung function was assessed for 12 hours or until death. Three dogs died prematurely in the control group, whereas only 1 dog died prematurely in the dimethylthiourea group. This resulted in a statistically significant difference in the average length of survival (p less than 0.05). Pulmonary artery and right atrial pressures were significantly lower in the dimethylthiourea group during the first 6 hours (p less than 0.05). Treatment with dimethylthiourea resulted in a significantly higher arterial oxygen tension at 4 hours, and intrapulmonary shunt tended to be lower. Thus, it would appear that dimethylthiourea has a protective effect on lungs preserved for 24 hours before tra...Continue Reading

References

Apr 1, 1989·The Journal of Surgical Research·D E PaullB R Wilcox
Feb 1, 1989·The Annals of Thoracic Surgery·D E PaullB R Wilcox
May 1, 1988·The Journal of Surgical Research·M J LynchM L Morganroth
Jun 1, 1984·The Annals of Thoracic Surgery·T P DowningN E Shumway

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Citations

Feb 22, 2002·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Shinji KosakaHiromi Wada
Mar 1, 1996·The Annals of Thoracic Surgery·R A SchmidG A Patterson
May 1, 1994·Free Radical Biology & Medicine·C P LewisB Nemery
Dec 28, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·S D CassiviS Keshavjee
Jan 15, 2005·Antioxidants & Redox Signaling·Takayuki NakamuraJunji Yodoi
Nov 28, 1997·American Journal of Respiratory Cell and Molecular Biology·J A DyeK L Dreher
Jan 22, 2013·The Annals of Thoracic Surgery·Zhigang TianThomas M Egan
Jun 11, 1991·The Annals of Thoracic Surgery·C J LambertB R Wilcox
Apr 1, 1991·The Annals of Thoracic Surgery·N D KonS A Mills
Jun 1, 1993·The Annals of Thoracic Surgery·T M EganB R Wilcox
Oct 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·C J SerrickH Shennib
May 1, 1993·The Annals of Thoracic Surgery·K S UlicnyB R Wilcox
Nov 11, 1991·The Annals of Thoracic Surgery·T M EganB R Wilcox
Sep 26, 1997·The Journal of Thoracic and Cardiovascular Surgery·A WatanabeH Takahashi
Feb 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·D A FullertonF L Grover
Sep 13, 2000·Scandinavian Cardiovascular Journal : SCJ·T VainikkaS P Mattila
Dec 21, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Dilip S NathRosemary F Kelly
Oct 14, 2009·European Biophysics Journal : EBJ·Elena A GolovinaFolkert A Hoekstra
May 1, 1995·The Journal of International Medical Research·P CarbognaniP Bobbio
Apr 9, 1991·Journal of Intensive Care Medicine·M I BiermanJ H Dauber
Sep 1, 1994·The Annals of Thoracic Surgery·M AoeG A Patterson

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