Oxygen free radicals and the systemic inflammatory response

IUBMB Life
Daniel Closa, Emma Folch-Puy

Abstract

The generation of oxygen free radicals is known to be involved in the development of the systemic inflammatory response syndrome. In addition to their actions as noxious mediators generated by inflammatory cells, these molecules play also a crucial role contributing to the onset and progression of inflammation in distant organs. In the early stages of the process, free radicals exert their actions via activation of nuclear factors, as NFkappaB or AP-1, that induce the synthesis of cytokines. In later stages, endothelial cells are activated due to the synergy between free radicals and cytokines, promoting the synthesis of inflammatory mediators and adhesion molecules. Finally, free radicals exert their toxic effects at the site of inflammation by reacting with different cell components, inducing loss of function and cell death. This review focuses on progress in the understanding the different actions of free radicals at the sequential stages of the development of the systemic inflammatory response.

Citations

Mar 12, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Neus Franco-PonsDaniel Closa
Feb 5, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Natasha SchvezovM Carolina Romero
Feb 19, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Armando Vega-LópezRicardo Dzul-Caamal
Feb 14, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Márcia Longaray-GarciaJosé Maria Monserrat
Mar 19, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ricardo Dzul-CaamalArmando Vega-López
Mar 19, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·M I Girón-PérezA Vega-López
Mar 20, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Kenneth B StoreyJanet M Storey
Sep 14, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·A L Patrício SilvaM J B Amorim
Mar 17, 2005·Mediators of Inflammation·Leszek TylickiBoleslaw Rutkowski
May 14, 2005·Critical Care Medicine·Roy D Goldfarb, Csaba Szabo
Jul 31, 2013·The American Journal of Chinese Medicine·Štefan TóthJuraj Guzy
May 7, 2010·Environmental Health : a Global Access Science Source·Ana L Miranda-VilelaMaria N Klautau-Guimarães
Feb 8, 2008·Journal of Zhejiang University. Science. B·Xi-ping ZhangHan-qin Chen
Dec 3, 2014·Chemico-biological Interactions·Volodymyr I Lushchak
Jan 30, 2014·Molecular and Cellular Endocrinology·Limor Raz
Mar 5, 2013·Annual Review of Plant Biology·Cathie MartinKatia Petroni
Jul 11, 2014·Current Opinion in Hematology·Jessica C CardenasJohn B Holcomb
Nov 15, 2011·Annual Review of Physiology·Elizabeth A BrowningAron B Fisher
Jul 30, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ignacio MontorfanoFelipe Simon
Sep 17, 2013·World Journal of Gastroenterology : WJG·Salim S Al-RejaieMohammed M Ahmed
Mar 28, 2012·Digestive Diseases and Sciences·Renata Minuzzo HartmannNorma Possa Marroni
Jul 31, 2013·Free Radical Research·Daniel Closa
Sep 29, 2015·Scandinavian Journal of Clinical and Laboratory Investigation·Wojciech ŁuczajElżbieta Skrzydlewska
Feb 25, 2005·Experimental Physiology·Marco A P BrottoThomas M Nosek
Apr 23, 2014·International Wound Journal·Mayank GautamSubrata B Ray
Aug 8, 2006·Biochemical Pharmacology·Bharat B AggarwalGautam Sethi
Jan 13, 2015·Preventive Nutrition and Food Science·Hyun Ah JungJae Sue Choi
Oct 11, 2011·Bioscience Reports·Gautam SethiVinay Tergaonkar
Jul 3, 2015·Oxidative Medicine and Cellular Longevity·Md Abu Taher SagorMd Ashraful Alam
May 3, 2015·Pharmacological Reports : PR·Gerlane C B GuerraRaimundo F Araújo Júnior
Dec 4, 2012·Brain, Behavior, and Immunity·B J RawdinO M Wolkowitz
Sep 24, 2011·International Immunopharmacology·Seung-Won YunSung-Joo Park

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Free Radical Biology & Medicine
I A ClarkW B Cowden
Free Radical Biology & Medicine
W A Pryor, S S Godber
Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Marcelo Hermes-Lima, Tania Zenteno-Savín
© 2022 Meta ULC. All rights reserved