Oxygen radical-dependent bacterial killing and pulmonary hypertension in piglets infected with group B streptococci

The American Review of Respiratory Disease
B D BowdyM N Gillespie

Abstract

The mechanism by which bacteria are cleared by the pulmonary circulation and the relation of this process to development of hemodynamic abnormalities are not understood. This study tested the hypotheses that clearance of Group B Streptococcus (GBS) during transit through the pulmonary circulation of infant piglets is related to oxygen radical-dependent bacterial killing and that killing of the organism is linked to development of pulmonary hypertension. GBS were radiolabeled with 111In and infused intravenously for 15 min (10(8) organisms/kg/min) into infant piglets ranging in age from 5 to 14 days. Lung specimens were excised at termination of the GBS infusion or 45 min thereafter, and both the relative deposition and viability of the bacteria were determined. The percentage of infused GBS recovered in lung tissue did not differ between the two time points (26 +/- 7% versus 29 +/- 8%), but the relative viability at termination of the infusion, 50 +/- 11%, was reduced to 19 +/- 4% within 45 min. Treatment with an oxygen radical scavenger, dimethylthiourea (DMTU), failed to influence the pulmonary deposition of GBS but significantly increased viability of the organism from 21.4 +/- 2.6 to 33.3 +/- 5.3%. As expected, GBS infusion...Continue Reading

References

Oct 1, 1988·The American Review of Respiratory Disease·T A BertramA R Brody
Mar 1, 1988·Chest·N C Staub
Mar 1, 1988·Journal of Applied Physiology·K MiyamotoN C Staub
Jun 1, 1986·Chest·K L Brigham
Dec 1, 1985·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·R GeigerM Jochum

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Citations

May 23, 2006·Infection and Immunity·Philipp Henneke, Reinhard Berner
Oct 8, 2008·Immunological Reviews·Julia Wennekamp, Philipp Henneke
May 13, 2006·Seminars in Fetal & Neonatal Medicine·Philipp Henneke, Reinhard Berner
Jul 1, 1993·The American Review of Respiratory Disease·J X LiJ B Philips
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sybille KenzelPhilipp Henneke

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