Oxygen-radical regulation of renal blood flow following suprarenal aortic clamping

Journal of Vascular Surgery
Stuart I MyersLori L Bartula

Abstract

Renal insufficiency continues to be complication that can affect patients after treatment for suprarenal aneurysms and renal artery occlusive disease. One proposed mechanism of renal injury after suprarenal aortic clamping (above the superior mesenteric artery) and reperfusion (SMA-SRACR) is the loss of microvascular renal blood flow with subsequent loss of renal function. This study examines the hypothesis that the loss of medullary and cortical microvascular blood flow following SMA-SRACR is due to oxygen-derived free radical down-regulation of endogenous medullary and cortical nitric oxide synthesis. Anesthetized male Sprague-Dawley rats (about 350 g) either had microdialysis probes or laser Doppler fibers inserted into the renal cortex (depth of 2 mm) and into the renal medulla (depth of 4 mm). Laser Doppler blood flow was continuously monitored. The microdialysis probes were connected to a syringe pump and perfused in vivo at 3 microL/min with lactated Ringer's solution. The animals were subjected to SMA-SRACR (or sham) for 30 minutes, followed by 60 minutes of reperfusion. Laser Doppler blood flow after the 30 minutes of SMA-SRACR followed by 60 minutes of reperfusion was compared with the time zero (basal) and with the c...Continue Reading

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Citations

Jun 8, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mohammed Koussai ChokPascal Eschwège
Mar 31, 2009·The Journal of Surgical Research·Senol GulmenIbrahim Meteoglu
Aug 22, 2014·Redox Report : Communications in Free Radical Research·Mamane SaniMossadok Ben-Attia
Jun 11, 2014·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Beatriz Prieto-MoureJosé Miguel Lloris Carsí
Oct 16, 2009·Current Opinion in Critical Care·Matthieu Le DorzeCan Ince
Aug 19, 2007·Chronobiology International·Mamane SaniMossadok Ben-Attia

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