PMID: 6408899Jan 1, 1983Paper

Oxygen radicals and vascular damage

Advances in Experimental Medicine and Biology
H A Kontos, M L Hess

Abstract

The effects of topical application of agents which produce oxygen radicals on cerebral arterioles were studied in anesthetized cats. Xanthine oxidase plus xanthine, which produced superoxide anion radical, hydrogen peroxide, and hydrogen peroxide plus ferrous sulfate, which produced the free hydroxyl radical, induced sustained dilation, reduced responsiveness to the vasoconstrictor effect of hypocapnia, and destructive lesions of the endothelium and of the vascular smooth muscle. Similar effects were produced by arachidonate, 15-HPETE, and PGG2. The effect of arachidonate was inhibited by mannitol, a free hydroxyl radical scavenger, the effect of PGG2 was inhibited by SOD, the effect of 15-HPETE was inhibited by either catalase or SOD. These results suggest that these cerebral vascular abnormalities were produced by a single destructive free radical, probably the hydroxyl free radical, generated via interaction of superoxide and hydrogen peroxide. Cerebral vascular abnormalities similar to those produced by oxygen radicals were also seen after experimental concussive brain injury or after acute hypertension. After brain injury, activation of phospholipase C and increased brain prostaglandin concentration were demonstrated. The ...Continue Reading

Citations

Jan 1, 1989·Annals of the New York Academy of Sciences·B D Watson, M D Ginsberg
Nov 1, 1987·Photochemistry and Photobiology·J S NelsonM W Berns
Jan 10, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marc A SeifmanM Cristina Morganti-Kossmann
May 16, 2017·International Journal of Molecular Sciences·Lucia MarsegliaEloisa Gitto
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M Ashraf
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Jan 1, 1988·Journal of Neuroscience Research·L Hillered, P H Chan
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Nov 14, 2002·Prostaglandins & Other Lipid Mediators·Shailaja KalyankrishnaKafait U Malik

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