Oxygen-releasing polycaprolactone/calcium peroxide composite microspheres.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Mengen ZhangWei Shen

Abstract

Oxygen-releasing polycaprolactone/calcium peroxide (PCL/CaO2 ) composite microspheres were fabricated via homogenization, electrospray with a single nozzle, and electrospray with a co-axial nozzle, resulting in homogenized, single-walled, and double-walled microspheres, respectively. Scanning electron microscopy revealed that homogenized microspheres had pores, while electrosprayed microspheres did not. Alizarin Red S staining showed a core-shell structure for double-walled microspheres. In a hypoxia incubator, single-walled, double-walled, and homogenized microspheres could maintain oxygen tension in PBS at or above 10% for approximately 5, 4, and 3 days, respectively. All the PCL/CaO2 microspheres could support viability of pancreatic β-cell line MIN6 cells in 2D cultures in a hypoxia incubator for 1 week, with the cells supported by double-walled and homogenized microspheres exhibiting the highest and the lowest metabolic activity, respectively. For 3D MIN6 cell cultures in a hypoxia incubator, single-walled and homogenized PCL/CaO2 microspheres led to the highest and the lowest live cell densities, respectively. Double-walled and single-walled microspheres provided the best support for 2D and 3D cultures, respectively, sugg...Continue Reading

References

Jun 21, 1996·The Journal of Biological Chemistry·J A KazzazS Horowitz
Apr 1, 1953·American Journal of Clinical Pathology·R K LOEFFLER, J SCUDDER
Sep 14, 2006·Tissue Engineering·Milica RadisicGordana Vunjak-Novakovic
Nov 21, 2008·Biomaterials·Se Heang OhBenjamin S Harrison
Jun 28, 2011·Acta Biomaterialia·Dawit G SeifuKibret Mequanint
Mar 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Eileen PedrazaCherie L Stabler
Aug 7, 2012·Journal of Biomedical Materials Research. Part a·Joseph C WhiteSurita R Bhatia
Aug 7, 2013·ACS Nano·Yu XiongHans Bäumler
Sep 1, 2014·International Journal of Pharmaceutics·Rajendar R MallepallyKevin R Ward
Nov 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Raymond P SeekellBrian D Polizzotti

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Citations

Feb 29, 2020·International Journal of Nanomedicine·Alan Is MoraisAnderson O Lobo
Jul 30, 2021·The Science of the Total Environment·Binliang WangKongxian Zhu
Sep 21, 2021·Cardiovascular Toxicology·Alireza JenabiMurugan Ramalingam

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