Oxygen tension gradients and heterogeneity in venous microcirculation: a phosphorescence quenching study

The American Journal of Physiology
R D Shonat, P C Johnson

Abstract

Localized measurements of intravascular oxygen tension (PO2) at multiple locations in the microvascular network of the rat spinotrapezius muscle were used to study the spatial distribution of PO2 in venular structures. By use of a newly developed phosphorescence system to rapidly and repeatedly measure PO2, 538 individual measurements were made in 18 different networks during rest. Average intravascular PO2 was (in mmHg +/- SD) 33 +/- 9, 21 +/- 9, 26 +/- 10, and 33 +/- 8 in small arcade arterioles, postcapillary venules (PV), 3 degrees venules (3V), and arcade venules, respectively. The coefficient of variation (CV), a descriptive indicator of spatial heterogeneity, was correspondingly 0.28, 0.45, 0.37, and 0.23 for the different vessel groups. PO2 was found to increase significantly (P < 0.001) from PV to 3V, rising 0.009 +/- 0.002 mmHg/microns along the vessel. By linear regression, the slope of PO2 for the vessel difference group, PV-3V as a function of mean systemic blood pressure (BPm; in mmHg) was -0.09 +/- 0.04 (P < 0.05), indicating that the measured longitudinal oxygen gradients and CV are only weakly dependent on BPm. The results support the hypothesis that oxygen can diffuse across the walls of postcapillary vessels ...Continue Reading

Citations

Jul 5, 2003·Physiological Reviews·Amy G TsaiMarcos Intaglietta
Mar 18, 2005·Journal of Applied Physiology·Paul C JohnsonMarcos Intaglietta
Dec 14, 2011·Biomedical Optics Express·Mitchell A DavisAndrew K Dunn
Oct 26, 2018·Physiological Reviews·Thomas P Keeley, Giovanni E Mann
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J J BishopP C Johnson
Jul 5, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Darin J SaltzmanPaul C Johnson
Sep 22, 2007·American Journal of Respiratory Cell and Molecular Biology·Pedro CabralesMarcos Intaglietta
Mar 10, 2010·Journal of Biomedical Optics·Mamta WankhedeBrian S Sorg
Nov 22, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Pang-Yu TengMahnaz Shahidi
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J J BishopP C Johnson
Oct 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Aleksander S GolubRoland N Pittman
Apr 1, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Aleksander S Golub, Roland N Pittman
Mar 4, 2014·American Journal of Hematology·Eduard J van BeersGregory J Kato
Oct 1, 2011·Free Radical Biology & Medicine·Mary A RobinsonCynthia M Otto

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