Oxygen therapy in patients with retinal artery occlusion: A meta-analysis

PloS One
Xiaodong WuYang Xu

Abstract

Oxygen therapy has been widely used for RAO (retinal artery occlusion) patients; however, inconsistent results have been reported. PubMed, Web of Science, EMBASE, Medline (OvidSP), Cochrane, China National Knowledge Infrastructure (CNKI), and Wanfang Database were examined. The primary endpoint was visual acuity (VA), and RevMan software 5.3 was used to statistically analyze the outcomes. Seven randomized controlled trials (RCTs) met the inclusion criteria. Patients who received oxygen therapy exhibited probability of visual improvement about 5.61 times compared with the control group who did not receive oxygen therapy (OR = 5.61; 95% CI, 3.60-8.73; p < 0.01). No statistically significant difference was observed between oxygen inhalation methods (Chi2 = 0.18, df = 1, p = 0.67), combined therapy (Chi2 = 0.21, df = 1, p = 0.64), or RAO type (Chi2 = 0.06, df = 1, p = 0.81). Conversely, 100% oxygen (Chi2 = 4.55, df = 1, p < 0.05) and hyperbaric oxygen (Chi2 = 4.55, df = 1, p < 0.05) significantly improved VA in RAO patients. Better effect was showed in period within 3 months (Chi2 = 5.76, df = 1, p < 0.05). The most effective treatment length was over 9 hours (Chi2 = 6.58, df = 1, p < 0.05). Oxygen therapy demonstrated beneficial e...Continue Reading

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Citations

Sep 5, 2020·The Journal of International Medical Research·Jun XiongYongxing Sun
Mar 14, 2020·Journal of Thrombosis and Thrombolysis·Daniel FerreiraPedro Castro
Jun 18, 2020·International Medical Case Reports Journal·Somya ChowdharyShailesh K Gupta
Aug 21, 2020·Journal of Pediatric Ophthalmology and Strabismus·Erbil SevenMuhammet Derda Özer
Feb 25, 2020·Case Reports in Ophthalmological Medicine·Ana Sofia LopesFrancisco Guerreiro
Feb 14, 2021·The Journal of Emergency Medicine·Hideaki L TanakaStephen R Hayden
Mar 27, 2021·Taiwan Journal of Ophthalmology·Rahul A SharmaValérie Biousse
Jun 20, 2021·Indian Journal of Ophthalmology·Cemal OzsaygılıHakan Ozdemir
Jun 20, 2021·Indian Journal of Ophthalmology·Ashish Ahuja, Piyush Kohli
Jul 19, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Raimo TuuminenPiotr Kanclerz
Dec 22, 2021·QJM : Monthly Journal of the Association of Physicians·Chia-Chen Hsieh, Wan-Ju Annabelle Lee

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Software Mentioned

OvidSP
RevMan

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