PMID: 2345Jun 30, 1975

Oxygen transport by haemoglobin. A comparison of whole blood, washed erythrocytes and haemoglobin solution

Biomedicine / [publiée Pour L'A.A.I.C.I.G.]
F LecompteJ J Pocidalo

Abstract

The properties of haemoglobin oxygen transport were compared under three different conditions: red cell in its natural medium, i.e. plasma (whole blood), washed red cell and haemoglobin A, the former suspended, the latter solved in an iso-osmotic tris buffer. The oxygen haemoglobin affinity (expressed as P50) and the respiratory Bohr effect variations were studied with modified media and unchanged pH and 2,3-diphosphoglycerate (2,3-DPG) concentration. Provided they are refered to intra-erythrocytic pH, none of these values were changed when varying environment. These results suggest that the three major ligands (H+ ions, 2,3-DPG and CO2) interaction with haemoglobin is largely predominant upon other factors which would interfere, and can completely account for oxygen transport by haemoglobin.

Related Concepts

Diphosphoglyceric Acids
Erythrocytes
Eryhem
Hydrogen-Ion Concentration
Ligands
Dioxygen

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