PMID: 6970018Feb 1, 1981Paper

Oxygen transport to tissue under normovolemic moderate and extreme hemodilution during coronary bypass operation

The Annals of Thoracic Surgery
J NiinikoskiM V Inberg

Abstract

Oxygen transport to tissue was studied in 12 patients undergoing coronary bypass operation under normovolemic moderate and extreme hemodilution. Normovolemic moderate hemodilution (15 ml per kilogram of body weight), carried out immediately after induction of anesthesia, decreased the mean hematocrit from 0.43 to 0.33. Simultaneously, the cardiac index and the left ventricular filling pressure increased slightly but the systemic oxygen transport was reduced by 20%. The subcutaneous tissue oxygen tension (PO2) was approximately 40 mm Hg after induction of anesthesia and underwent a transient increase during moderate hemodilution. During cardiopulmonary bypass and extreme hemodilution, the mean hematocrit declined to 0.16. Concurrently, the mean tissue PO2 fell sharply and reached a minimum of 14 mm Hg at deepest hypothermia. After decannulation and reinfusion of autologous blood, the PO2 rose to 30 mm Hg. In general, total-body oxygen consumption changed along with tissue PO2. Blood lactate concentration underwent a clear increase in the early phase of extracorporeal circulation and remained rather stationary thereafter. No perioperative myocardial infarctions were encountered, and each patient made an uneventful recovery.

References

Feb 1, 1978·The Annals of Thoracic Surgery·P Lilleaasen, O Stokke
Oct 1, 1977·The Annals of Thoracic Surgery·G D Buckberg
Jan 1, 1975·Pflügers Archiv : European journal of physiology·W von RestorffE Bassenge
Jun 1, 1974·British Journal of Anaesthesia·E A HarrisB G Barratt-Boyes
Jul 1, 1974·The Annals of Thoracic Surgery·J J VerskaL A Brewer
Jan 25, 1973·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·K MessmerM Kessler
Jan 1, 1972·Surgery·J Ninikoski, T K Hunt
Jan 1, 1961·Circulation Research·A C GUYTON, T Q RICHARDSON

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Citations

Nov 6, 2001·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·H KawataH Matsuda
Apr 29, 1998·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·T SakamotoN Kosai
Dec 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Richard A JonasJane W Newburger
Jun 3, 1999·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·J A RousouS G Owen
Aug 31, 2002·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Uwe Kreimeier, Konrad Messmer
Apr 1, 1991·British Journal of Urology·M TaljaO Alfthan
Jul 1, 1983·American Journal of Surgery·R T SchallerE B Furman
Dec 1, 1984·Journal of Pediatric Surgery·R T SchallerE B Furman
Jan 1, 1996·Journal of Cardiothoracic and Vascular Anesthesia·B D Spiess, R P Cochran
Jan 1, 1994·Perfusion·V T TsangR B Mee
Apr 15, 2014·Seminars in Cardiothoracic and Vascular Anesthesia·Allison Bechtel, Julie Huffmyer
Oct 20, 1999·The Annals of Otology, Rhinology, and Laryngology·J KallinenR Grénman
Jun 11, 1991·Journal of Cardiac Surgery·K S Ulicny, L F Hiratzka
Feb 1, 1987·World Journal of Surgery·K F Messmer
Jul 1, 1991·Journal of Clinical Monitoring·H O Soini, J Takala
Jan 1, 1994·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·W L HolmanA D Pacifico
May 23, 2002·Perfusion·Y M GanushchakD S de Jong

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