Oxygen uptake and tissue oxygen tension during adrenergic stimulation in canine subcutaneous adipose tissue

Acta Physiologica Scandinavica
B B FredholmP C Johnson

Abstract

The effect of sympathetic nerve stimulation (NS) and injected noradenaline (NA) or isoprenaline (Iso) on PVO2, VO2 and PtO2 was studied in isolated canine subcutaneous adipose tissue. These effects were compared to those produced by mechanical blood flow reduction (clamping). Resting VO2 measured 13.0+/- 2.3 mumol X min-1 X 100 g-1. When blood flow was reduced by 20% or less there was no significant change of VO2. Reducing blood flow to 50% of control or less by NS caused a parallel reduction in VO2, while clamping reduced VO2 significantly less. NA gave effects similar to those of NS. After NS or NA there was a period of hyperemia and increased oxygen extraction which more than compensated for the decrease in VO2 during vasoconstriction. Such a net increase in VO2 was not produced by clamping. Control PtO2 averaged 29+/-2 mmHg. NA reduced it by 70% and clamping to the same blood flow level only by 14% (p less than 0.01). Thus, a mere reduction in blood flow has little effect on PtO2, while blood flow reduction combined with redistribution of blood flow and an increased oxygen deman can lead to tissue hypoxia.

References

Dec 1, 1970·Acta Physiologica Scandinavica·B B Fredholm, J Karlsson
Jan 1, 1973·Scandinavian Journal of Clinical and Laboratory Investigation·B B FredholmB Persson
Apr 1, 1973·The American Journal of Physiology·W J WhalenC A Thuning
May 1, 1973·Microvascular Research·W J WhalenR A Ganfield
Jun 1, 1974·Acta Physiologica Scandinavica·B B Fredholm, A Fronek
Sep 1, 1972·The American Journal of Physiology·G Beer, L R Yonce
Aug 1, 1970·Acta Physiologica Scandinavica·B B FredholmS Rosell
Dec 1, 1970·Acta Physiologica Scandinavica·C Lindquist
May 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·O D Mjös, S Akre
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·P Henningsen
Jan 1, 1966·Journal of Applied Physiology·R G Rossing, S M Cain
Sep 1, 1967·Acta Physiologica Scandinavica·B Oberg, S Rosell
Nov 1, 1967·Journal of Applied Physiology·W J WhalenP Nair
Jan 1, 1959·Pflügers Archiv : European journal of physiology·H BARTELS, H HARMS
Aug 2, 1912·The Journal of Physiology·F Verzár

❮ Previous
Next ❯

Citations

Jun 1, 1978·Journal of Neurochemistry·P Kontro, S S Oja
Feb 1, 1979·Acta Physiologica Scandinavica·E BelfrageB B Fredholm
Mar 1, 1979·Acta Physiologica Scandinavica·B B Fredholm, P Hjemdahl
Jan 1, 1984·Scandinavian Journal of Plastic and Reconstructive Surgery·G Arturson, M Hjelm
Jan 1, 1976·Scandinavian Journal of Plastic and Reconstructive Surgery·G Jurell, C E Jonsson
Jun 1, 1990·Scandinavian Journal of Clinical and Laboratory Investigation·R Jelnes
Oct 18, 2018·Praxis·Martin Schläpfer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.