Oxygen uptake kinetics: historical perspective and future directions

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Richard L Hughson

Abstract

Oxygen uptake has been studied in the transitions between rest and exercise for more than 100 years, yet the mechanisms regulating the rate of increase in oxidative metabolism remain controversial. Some of the controversy is a consequence of incorrect interpretations of kinetic parameters describing amplitude and time constant relationships, whereas other factors relate to an incomplete framework for interpretation of experimental results. In this review, a new conceptual 3-dimensional model is proposed to explore the intracellular environment of skeletal muscle in the rest-to-exercise transition. The model incorporates the so-called "metabolic inertia" describing the increases in metabolic substrates and enzyme activation, along with the dynamic changes in intracellular partial pressure of oxygen (PO2). Considerable evidence exists during normal submaximal exercise challenges for an effect of changes in O2 delivery to working muscles affecting the intracellular PO2 (displayed on the x axis) and the high energy phosphate concentration (y axis) during steady-state exercise as well as the transitions from rest to exercise. The z axis incorporates a hypothetical description of metabolic inertia that is enhanced by increased enzyme...Continue Reading

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Citations

Dec 31, 2010·European Journal of Applied Physiology·Richard L Hughson, Azmy Faisal
Jul 1, 2011·European Journal of Applied Physiology·Nicola LaiMarco E Cabrera
Jun 12, 2012·European Journal of Applied Physiology·Brittany A EdgettBrendon J Gurd
Nov 3, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Audrey Borghi-SilvaDirceu Costa
Jan 31, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·David W Hill
Jun 30, 2014·European Journal of Applied Physiology·Joshua P NederveenJuan M Murias
Feb 12, 2014·Thyroid : Official Journal of the American Thyroid Association·Francisco Zacaron WerneckMário Vaisman
Dec 15, 2015·European Journal of Applied Physiology·U HoffmannU Drescher
Jul 13, 2012·Neurorehabilitation and Neural Repair·Dominique HansenBert O Eijnde
Jun 2, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Thomas BeltrameRichard L Hughson
Oct 19, 2017·European Journal of Applied Physiology·Duncan J Macfarlane
Jan 3, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Natasha G BoyesCorey R Tomczak
Mar 28, 2019·Canadian Journal of Physiology and Pharmacology·J KoschateU Hoffmann
Oct 22, 2019·Free Radical Research·Jingke GuoPingfan Rao
Nov 3, 2016·Journal of Strength and Conditioning Research·Henrique P NeivaDaniel A Marinho
Aug 20, 2019·Lasers in Medical Science·Stephanie Nogueira LinaresAparecida Maria Catai
Mar 7, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Simon GreenMikel Egaña
Jun 23, 2019·European Journal of Applied Physiology·Jessica KoschateUwe Hoffmann
Jun 15, 2013·Journal of Applied Physiology·Alan P BensonHarry B Rossiter
Nov 20, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas Beltrame, Richard L Hughson

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