PMID: 8599284Jan 1, 1995Paper

Oxygen uptake/oxygen supply dependency: fact or fiction?

Acta Anaesthesiologica Scandinavica. Supplementum
J L Vincent, D De Backer

Abstract

More than a decade ago, observations of co-variance between VO2 and DO2 led to the identification of a condition known as pathological O2 supply dependency. This condition was subsequently observed in critically ill patients with sepsis and acute circulatory failure. More recently, other authors have challenged the existence of this condition, often citing methodologic problems or mathematical coupling to account for spurious observations in the earlier studies. Here, we review the evidence for and against pathological O2 supply dependency. We find that many of the arguments have some validity but only in specific circumstances. We conclude, therefore, that pathological O2 supply dependency is a hallmark of acute circulatory failure and that an effective therapeutic approach should be based on an evaluation of organ system function in each individual case. Parameters such as blood lactate, pHi and veno-arterial PCO2 may be useful in this respect.

References

Aug 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S M Cain
Jan 1, 1992·Clinical Science·C J GreenI T Campbell
Sep 1, 1992·British Journal of Anaesthesia·S B BhattM Mak
May 1, 1991·Journal of Applied Physiology·R SchlichtigM R Pinsky
Jul 1, 1991·Journal of Applied Physiology·P Van der LindenJ L Vincent
Jun 1, 1991·The American Review of Respiratory Disease·J J RoncoJ A Russell
Jul 1, 1990·The American Review of Respiratory Disease·J L VincentR J Kahn
Aug 1, 1989·Critical Care Medicine·J TuchschmidtO P Sharma
Nov 1, 1989·Critical Care Medicine·J D EdwardsE B Faragher
Jun 1, 1988·Journal of Applied Physiology·D P NelsonP T Schumacker
Jun 1, 1988·Journal of Applied Physiology·R B Light
May 1, 1987·Journal of Applied Physiology·H H StrattonJ C Newell
Aug 13, 1987·The New England Journal of Medicine·R R WolfeM Wolfe
Nov 1, 1987·Critical Care Medicine·I H Abdul-RasoolD S Ward
Feb 1, 1987·The American Journal of Cardiology·S H KuboR J Cody
Jun 1, 1985·The American Review of Respiratory Disease·M T HauptR W Carlson
Sep 1, 1965·The American Journal of Physiology·S M Cain
Nov 11, 1965·The American Journal of Physiology·F J KlockeE Braunwald
Aug 1, 1983·Critical Care Medicine·K ShibutaniD V Bizzarri
Jan 1, 1982·The Journal of Surgical Research·S E LandauR D Goldfarb
Mar 1, 1981·Annals of Surgery·J P Archie
Oct 1, 1994·The Journal of Surgical Research·H ZhangJ L Vincent
Jun 16, 1994·The New England Journal of Medicine·M A HayesD Watson

❮ Previous
Next ❯

Citations

Jul 23, 2003·The Journal of Surgical Research·David W HartDennis C Gore
Oct 24, 2003·The Journal of Surgical Research·David W HartDavid L Chinkes
Nov 4, 2011·Critical Care : the Official Journal of the Critical Care Forum·Paul van BeestMichaël Kuiper
Oct 1, 2014·Intensive Care Medicine·Jean-Louis Vincent, Daniel De Backer
Nov 1, 1996·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·M Takaori, A Fukui
Oct 29, 2008·Clinics in Chest Medicine·Emanuel P RiversDavid Amponsah
Jan 22, 2013·Respiratory Physiology & Neurobiology·Philippe Haouzi, Andry Van de Louw
May 24, 2016·The Journal of Emergency Medicine·Nikhil GoyalEmanuel P Rivers
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·X M Leverve

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Critical Care : the Official Journal of the Critical Care Forum
Wolfgang StahlHendrik Bracht
European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
Y IimuroY Matsumoto
Pflügers Archiv : European journal of physiology
F LecompteJ J Pocidalo
© 2021 Meta ULC. All rights reserved