Oxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): a randomised, double-blind, paired, phase 3 trial

Lancet
Ina JochmansCOMPARE Trial Collaboration and Consortium for Organ Preservation in Europe (COPE)

Abstract

Deceased donor kidneys are preserved in cold hypoxic conditions. Providing oxygen during preservation might improve post-transplant outcomes, particularly for kidneys subjected to greater degrees of preservation injury. This study aimed to investigate whether supplemental oxygen during hypothermic machine perfusion (HMP) could improve the outcome of kidneys donated after circulatory death. This randomised, double-blind, paired, phase 3 trial was done in 19 European transplant centres. Kidney pairs from donors aged 50 years or older, donated after circulatory death, were eligible if both kidneys were transplanted into two different recipients. One kidney from each donor was randomly assigned using permuted blocks to oxygenated hypothermic machine perfusion (HMPO2), the other to HMP without oxygenation. Perfusion was maintained from organ retrieval to implantation. The primary outcome was 12-month estimated glomerular filtration rate (eGFR) using the Chronic Kidney Disease Epidemiology Collaboration equation in pairs of donated kidneys in which both transplanted kidneys were functioning at the end of follow-up. Safety outcomes were reported for all transplanted kidneys. Intention-to-treat analyses were done. This trial is registe...Continue Reading

References

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Citations

Jan 28, 2021·International Journal of Molecular Sciences·Maria Irene BelliniVito D'Andrea
Dec 23, 2020·Artificial Organs·Robert TatumVakhtang Tchantchaleishvili
Mar 7, 2021·International Journal of Molecular Sciences·Ruta ZulpaitePeter Schemmer
May 20, 2021·Transplantation·Oliver McCallion, Fadi Issa
May 27, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Jason B DoppenbergHenri G D Leuvenink
Aug 21, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rémi LenainUNKNOWN Contributors to the CRISTAL National Registry
Aug 24, 2021·British Journal of Anaesthesia·Kasia D BeraRutger Ploeg
Aug 28, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·L Leonie van LeeuwenHenri G D Leuvenink
Aug 28, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Xavier MullerJean-Yves Mabrut
Aug 28, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Rianne SchutterRonald J H Borra
Aug 28, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Ann Etohan OgbemudiaJulien Branchereau
Aug 31, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Emanuele CozziUNKNOWN for ESOT Workstream 1 of the TLJ (Transplantation Learning Journey) Project
Sep 28, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Julie De BeuleIna Jochmans
May 14, 2021·Transplantation·Sarah A HosgoodMichael L Nicholson
Jun 20, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Ina JochmansUNKNOWN ESOT Workstream 04 of the TLJ (Transplant Learning Journey) project

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