PMID: 18717508Aug 23, 2008Paper

Oxymorphone and oxymorphone extended release: a pharmacotherapeutic review

Journal of Opioid Management
Paul Sloan, Robert L Barkin

Abstract

The treatment of chronic pain remains an enormous challenge in the United States. Opioid analgesics are an important component of pharmacotherapy for chronic pain and have proven efficacy in the management of cancer and noncancer chronic pain. The newest addition to oral opioid pharmacotherapy is oral oxymorphone, a semisynthetic opioid agonist that is now available in oral immediate-release (IR) and extended-release (ER) formulations. This review discusses the pharmacology, pharmacokinetics, pharmacodynamics, pharmacotherapeutics, and clinical use of oral oxymorphone IR and ER formulations for the management of moderate to severe pain for different types of patients in a variety of settings. Two published studies evaluated the efficacy and safety of oxymorphone IR in patients with moderate to severe postoperative pain and demonstrated that it provides rapid and effective analgesia and is generally well tolerated. Six published randomized controlled trials and three published open-label studies evaluated the efficacy and safety of oxymorphone ER for chronic cancer or noncancer pain. These trials found analgesic efficacy and tolerability comparable to that provided by morphine controlled release (CR) or oxycodone CR; treatment e...Continue Reading

Citations

Jul 31, 2009·Postgraduate Medicine·Edward J Cone, Yale H Caplan
Apr 14, 2016·Expert Opinion on Drug Safety·Michael Harned, Paul Sloan
Mar 13, 2014·Clinical Orthopaedics and Related Research·Joseph A KaramJavad Parvizi
May 11, 2010·Drugs & Aging·Howard Smith, Patricia Bruckenthal
Dec 5, 2013·Expert Opinion on Drug Delivery·Paul Sloan
Jul 10, 2018·Journal of Clinical Pharmacology·Anne N Nafziger, Robert L Barkin
Jun 22, 2021·Anesthesiology and Pain Medicine·Sanam DolatiHassan Soleimanpour
Feb 13, 2010·The Journal of Arthroplasty·Zachary D PostWilliam J Hozack

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