Oxyntic gland neoplasm of the stomach: expanding the spectrum and proposal of terminology.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Tetsuo UshikuMasashi Fukayama

Abstract

Gastric neoplasms exhibiting oxyntic gland differentiation typically are composed of cells with mild cytonuclear atypia differentiating to chief cells and to a lesser extent, parietal cells. Such tumors with atypical features have been reported also and terminology for this entity remains a matter of considerable debate. We analyzed and classified 26 tumors as oxyntic gland neoplasms within mucosa (group A, eight tumors) and with submucosal invasion. The latter was divided further into those with typical histologic features (group B, 14 tumors) and atypical features, including high-grade nuclear or architectural abnormality and presence of atypical cellular differentiation (group C, four tumors). Groups A and B tumors shared similar histologic features displaying either a chief cell predominant pattern characterized by monotonous chief cell proliferation, or a well-differentiated mixed cell pattern showing admixture of chief and parietal cells resembling fundic gland. In addition, group C tumors displayed atypical cellular differentiation, including mucous neck cell and foveolar epithelium. Moderate or even marked cytological atypia was noted in group C, whereas it was usually mild in the other groups except for three group B t...Continue Reading

References

Jul 6, 2007·Pathology International·Tetsuya TsukamotoMasae Tatematsu
Apr 23, 2010·The American Journal of Surgical Pathology·Hiroya UeyamaSumio Watanabe
Apr 5, 2012·The American Journal of Surgical Pathology·Aatur D SinghiElizabeth A Montgomery
Aug 27, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Takashi MitsuiYasuyuki Seto
Dec 11, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Tetsuya UeoTetsuya Ishida
Apr 24, 2014·Endoscopy·Yasuhiko HamadaYoshiyuki Takei
Sep 4, 2015·Histopathology·Karen ChanM Priyanthi Kumarasinghe
Sep 15, 2016·Clinical Journal of Gastroenterology·Yoshinori SatoFumio Itoh
Apr 13, 2018·American Journal of Clinical Pathology·Mark A BenedictDhanpat Jain

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Citations

Jan 1, 2021·Histopathology·Bence KőváriGregory Y Lauwers
Jan 21, 2021·Microorganisms·Simone BertzMichael Vieth
Jul 10, 2021·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kentaro ImamuraAkinori Iwashita
Dec 8, 2020·The American Journal of Surgical Pathology·Elizabeth A MontgomeryAatur D Singhi

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surgical resection

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