PMID: 3748850Jan 1, 1986Paper

Oxyntomodulin and its C-terminal octapeptide inhibit liquid meal-stimulated acid secretion

Peptides
C JarrousseD P. Bataille

Abstract

Oxyntomodulin (OXM), a 37-amino acid glucagon-containing peptide produced mainly in intestine and endocrine pancreas, is present in rat plasma and inhibits pentagastrin-stimulated gastric acid secretion in both the anesthetized and the conscious rat. In order to investigate the modifications in acid and water secretions in a physiological model, we set up a protocol which allowed us to study acid secretion in the conscious rat both under basal conditions (during an 18-hour fast) or after a physiological stimulus (a liquid meal). OXM (110 pmol X kg-1) did not modify the basal acid or water output in an 18-hour fasting state. When injected before the test meal, OXM (225 pmol X kg-1) sharply decreased the acid output stimulated by a liquid meal (milk), which represented 10 times the basal value. Results are compared to those obtained when pentagastrin was the stimulant. Synthetic C-terminal octapeptide of OXM was able to inhibit both basal and meal-stimulated secretions. We can conclude that OXM, or a closely related peptide containing the C-terminal octapeptide, may be a physiological regulator of gastric functions.

Citations

Sep 1, 1989·Digestive Diseases and Sciences·B SchjoldagerJ J Holst
Nov 12, 1991·Biochimica Et Biophysica Acta·T TaniD Bataille
Jan 1, 1986·Peptides·D BatailleM Dubrasquet
Oct 1, 1994·Molecular and Cellular Endocrinology·F RenéJ M Félix
May 14, 1999·Trends in Endocrinology and Metabolism : TEM·D J Drucker
Jan 1, 1994·Digestive Diseases and Sciences·I A Gómez de SeguraJ A Rodríguez Montes
Jan 1, 1988·Annals of the New York Academy of Sciences·D BatailleS Lotersztajn
Jun 1, 1989·Bioscience Reports·G C NikouS R Bloom
Sep 21, 2001·Endocrinology·C L DakinS R Bloom
Jan 11, 2013·Physiological Reviews·Sascha Kopic, John P Geibel
Oct 1, 1989·International Journal of Peptide and Protein Research·A AumelasJ Martinez

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