Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial.

International Journal of Obesity : Journal of the International Association for the Study of Obesity
K WynneS R Bloom

Abstract

Oxyntomodulin has recently been found to decrease body-weight in obese humans and may be a potential anti-obesity therapy. To determine whether oxyntomodulin alters energy expenditure, in addition to reducing energy intake, in 'free-living' overweight and obese volunteers. Randomized double-blind controlled cross-over trial. Community and hospital-based. Fifteen healthy overweight and obese men and women (age: 23-49 years, BMI: 25.1-39.0 kg/m(2)). All volunteers completed the study protocol. Four-day subcutaneous self-administration of pre-prandial oxyntomodulin, three times daily. Participants were advised to maintain their normal dietary and exercise regimen. (1) Energy expenditure, measured by indirect calorimetry and combined heart rate and movement monitoring; (2) energy intake, measured during a study meal. Oxyntomodulin administration reduced energy intake at the study meal by 128+/-29 kcal (P=0.0006) or 17.3+/-5.5% (P=0.0071), with no change in meal palatability. Oxyntomodulin did not alter resting energy expenditure; but increased activity-related energy expenditure by 143+/-109 kcal/day or 26.2+/-9.9% (P=0.0221); total energy expenditure by 9.4+/-4.8% (P=0.0454) and physical activity level by 9.5+/-4.6% (P=0.0495). A ...Continue Reading

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Citations

Sep 10, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Y-L LiuS R Bloom
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·O B ChaudhriS R Bloom
Jun 20, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S S Hussain, S R Bloom
Mar 13, 2013·Nature Reviews. Endocrinology·Sharon A Sadry, Daniel J Drucker
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Feb 28, 2008·Current Opinion in Gastroenterology·Louis Chaptini, Steven Peikin
Oct 17, 2007·Annual Review of Physiology·Owais B ChaudhriStephen R Bloom
Sep 29, 2011·Journal of Obesity·Keisuke SuzukiStephen R Bloom
Jan 4, 2007·The Journal of Clinical Investigation·Daniel J Drucker
Jan 4, 2007·The Journal of Clinical Investigation·David E Cummings, Joost Overduin
Dec 4, 2008·The Journal of Clinical Endocrinology and Metabolism·Stephen C Woods, David A D'Alessio
Apr 29, 2010·Endocrine Journal·Keisuke SuzukiStephen R Bloom
Sep 29, 2012·The Journal of Endocrinology·Alessandro Pocai
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Nov 20, 2013·Gastroenterology Research and Practice·S D Pedersen
Dec 5, 2013·Physiological Reports·Auyon MukharjiSteven J Swoap
Aug 18, 2012·Experimental Diabetes Research·Keisuke SuzukiStephen R Bloom
Aug 15, 2014·Diabetes Research and Clinical Practice·Dominique Bataille, Stéphane Dalle
Feb 7, 2014·British Medical Bulletin·Benjamin C T Field
Jan 1, 2014·Journal of Clinical Medicine·Dante J MerlinoScott A Waldman
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Jun 15, 2011·Expert Review of Clinical Pharmacology·Gilbert W KimScott A Waldman
Oct 14, 2008·Expert Opinion on Biological Therapy·Nicole C KestyDavid Maggs
Apr 30, 2013·Expert Opinion on Drug Discovery·Gilbert W KimScott A Waldman
Sep 9, 2015·Journal of Gastroenterology·Timothy Sean KairupanAkio Inui
Jan 19, 2016·Trends in Molecular Medicine·Matija Sestan-Pesa, Tamas L Horvath
Sep 14, 2014·The Journal of Physiology·R V ScottS R Bloom
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Aug 7, 2010·Pharmacology, Biochemistry, and Behavior·G A Kennett, P G Clifton
Mar 6, 2010·Gastroenterology Clinics of North America·Amy E Foxx-Orenstein
Feb 5, 2016·Current Therapeutic Research, Clinical and Experimental·Samantha L PriceStephen R Bloom
Jun 30, 2009·Pharmacology & Therapeutics·Marianne T Neary, Rachel L Batterham

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