Oxysterols are increased in plasma of end-stage renal disease patients

Kidney & Blood Pressure Research
Werner SiemsIngrid Wiswedel

Abstract

Oxidative stress occurs in chronic renal failure patients undergoing hemodialysis (HD). The objective of our study was to measure oxidation products of cholesterols, so-called oxysterols, in the serum of HD patients in comparison to healthy control persons. In 42 HD patients, plasma oxysterols were measured before and after HD. The values were compared with those in 40 healthy controls. The following cholesterol derivatives were analyzed: dienes, 7beta-OH, beta-epoxy, alpha-epoxy, 20alpha-OH, alpha-triol, and 7-keto cholesterol. In HD patients, serum levels of oxysterols are increased in comparison to controls. The highest values were measured for beta-epoxy cholesterol and for 20alpha-OH cholesterol. During HD oxysterol concentrations increased, obviously by water removal and concentration of nondialyzable compounds. Due to oxidative stress which is known as a typical sign of chronic renal failure the plasma concentrations of oxysterols are also significantly increased in comparison to healthy controls. This underlines the data on accelerated lipid peroxidation in end-stage renal disease (ESRD) patients. Accumulated oxysterols which are accused of exerting atherosclerosis-stimulating effects, which can contribute to the increa...Continue Reading

References

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Citations

Sep 15, 2010·Free Radical Research·Corinne M SpickettNeven Zarkovic
Jul 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Liang LuMiriam F Weiss
Aug 9, 2007·Bioorganicheskaia khimiia·A V AntonchikV A Khripach
Dec 30, 2009·Pharmacological Reviews·Chih-Yen ChenAkio Inui
Jul 14, 2019·The Journal of Steroid Biochemistry and Molecular Biology·Irundika Hk DiasPablo Martinez-Lage
Mar 13, 2021·Oxidative Medicine and Cellular Longevity·Krzysztof GwozdzinskiLukasz Gwozdzinski

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