Oxytocin and vasopressin flatten dominance hierarchy and enhance behavioral synchrony in part via anterior cingulate cortex

Scientific Reports
Yaoguang Jiang, Michael L Platt

Abstract

The neuropeptides oxytocin (OT) and arginine vasopressin (AVP) influence social functions in many mammals. In humans and rhesus macaques, OT delivered intranasally can promote prosocial behavior in certain contexts. Yet the precise neural mechanisms mediating these behavioral effects remain unclear. Here we show that treating a group of male macaque monkeys intranasally with aerosolized OT relaxes their spontaneous social interactions with other monkeys. OT reduces differences in social behavior between dominant and subordinate monkeys, thereby flattening the status hierarchy. OT also increases behavioral synchrony within a pair. Intranasal delivery of aerosolized AVP reproduces the effects of OT with greater efficacy. Remarkably, all behavioral effects are replicated when OT or AVP is injected focally into the anterior cingulate gyrus (ACCg), a brain area linked to empathy and other-regarding behavior. ACCg lacks OT receptors but is rich in AVP receptors, suggesting exogenous OT may shape social behavior, in part, via nonspecific binding. Notably, OT and AVP alter behaviors of both the treated monkey and his untreated partner, consistent with enhanced feedback through reciprocal social interactions. These findings bear importa...Continue Reading

References

Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C A Pedersen, A J Prange
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T R Insel, L E Shapiro
May 7, 1982·Science·C A PedersenA J Prange
Feb 1, 1995·Brain : a Journal of Neurology·O DevinskyB A Vogt
Jan 1, 1997·Reviews of Reproduction·T R InselZ Wang
May 1, 1999·Journal of Neuroendocrinology·L J YoungT R Insel
Jul 11, 2000·Nature Genetics·J N FergusonJ T Winslow
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·F ChampagneM J Meaney
Feb 8, 2003·Journal of Neurophysiology·K A HadlandR E Passingham
Mar 4, 2003·Nature Reviews. Neuroscience·Ralph Adolphs
Sep 29, 2004·Nature Neuroscience·Larry J Young, Zuoxin Wang
Jun 3, 2005·Nature·Michael KosfeldErnst Fehr
Jun 11, 2005·Psychoneuroendocrinology·Karen J ParkerDavid M Lyons
Oct 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yuki TakayanagiKatsuhiko Nishimori
Aug 15, 2006·Biological Psychiatry·Eric HollanderStacey Wasserman
Sep 2, 2006·Science·P H RudebeckM F S Rushworth
Dec 2, 2006·Biological Psychiatry·Gregor DomesSabine C Herpertz
Sep 25, 2007·Biological Psychiatry·Adam J GuastellaMark R Dadds
Nov 8, 2007·PloS One·Paul J ZakSheila Ahmadi
Mar 18, 2008·Biological Psychiatry·Adam J GuastellaFrosso Mathews
Jul 29, 2008·Progress in Brain Research·Jennifer A Bartz, Eric Hollander
Sep 20, 2008·Journal of Psychopharmacology·M Di SimplicioCatherine J Harmer
Nov 8, 2008·Science·Zoe R Donaldson, Larry J Young
Nov 14, 2008·Nature·Timothy E J BehrensMatthew F S Rushworth
Jan 9, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ulrike RimmelePeter Klaver
Jan 21, 2009·Psychological Science·Scott S Wiltermuth, Chip Heath
Jan 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthias BeckmannMatthew F S Rushworth
May 30, 2009·Science·Timothy E J BehrensMatthew F S Rushworth
Jun 2, 2009·Frontiers in Neuroendocrinology·Heather E Ross, Larry J Young
Jul 28, 2009·Psychoneuroendocrinology·Gregor DomesSabine C Herpertz
Jul 31, 2009·Biological Psychiatry·Simone G Shamay-TsooryYechiel Levkovitz
Oct 31, 2009·Journal of Pharmaceutical Sciences·Shyeilla V DhuriaWilliam H Frey
Nov 6, 2009·Current Biology : CB·Jeffrey T KleinMichael L Platt
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Elissar AndariAngela Sirigu
Feb 27, 2010·Psychopharmacology·Abigail A MarshR J R Blair
Mar 6, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin Y Hayden, Michael L Platt
Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Matthias GamerChristian Büchel

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Citations

Oct 4, 2018·American Journal of Primatology·Melissa D BaumanMichael L Platt
Jul 31, 2019·American Journal of Primatology·Melissa R BergKristine Coleman
Jul 31, 2019·Cold Spring Harbor Symposia on Quantitative Biology·Adam Kepecs
Sep 14, 2018·Frontiers in Behavioral Neuroscience·Olga L LopatinaAlla B Salmina
Oct 28, 2019·Scientific Reports·Jessica TaubertLeslie G Ungerleider
Oct 12, 2018·Proceedings. Biological Sciences·L SamuniC Crockford
Jun 14, 2019·Nature·Yang ZhouShihua Yang
Dec 24, 2018·Scientific Reports·Yaoguang Jiang, Michael L Platt
Jan 20, 2021·Hormones and Behavior·Natanja F PeenBrian C Trainor
Jan 4, 2021·Psychoneuroendocrinology·James BrooksShinya Yamamoto
Jun 9, 2021·Neuroscience and Biobehavioral Reviews·Andrey E Ryabinin, Hannah D Fulenwider
May 13, 2021·Genes, Brain, and Behavior·Kayla R NygaardJoseph D Dougherty
Jul 21, 2021·Trends in Cognitive Sciences·Sylvia WirthAngela Sirigu

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