Oxytocin and vasopressin modulation of social anxiety following adolescent intermittent ethanol exposure

Psychopharmacology
Carol A DannenhofferLinda Spear

Abstract

Adolescent intermittent ethanol exposure (AIE) produces lasting, sex-specific social anxiety-like alterations in male, but not female rats. Oxytocin (OXT) and vasopressin (AVP) brain systems play opposite roles in regulating social preference/avoidance, with OXT increasing approach to, and AVP increasing avoidance of social stimuli. To test the hypothesis that social anxiety-like alterations seen in adult males after AIE are associated with a shift in the balance between OXT and AVP toward AVP, effectiveness of pharmacological activation of the OXT system and blockade of endogenous activity at AVP receptors for reversing AIE-induced social anxiety-like alterations was assessed, along with examination of the effects of AIE on OXT, vasopressin V1a, and V1b receptor (OXT-R, V1a-R, and V1b-R) surface expression in the hypothalamus. Sprague-Dawley male and female rats were given 4 g/kg ethanol (AIE) or water intragastrically every 48 h for a total of 11 exposures during postnatal days (P) 25-45. On P70-72, animals were given a social interaction test following administration of a selective OXT-R agonist WAY-267464, selective V1a-R antagonist SR-49059, or V1b-R antagonist SSR-149415, and hypothalamic tissue was collected. Social anxi...Continue Reading

References

Jun 12, 1992·Annals of the New York Academy of Sciences·C F FerrisT R Insel
May 1, 1992·Neurotoxicology and Teratology·R R Holson, B Pearce
Mar 1, 1997·Developmental Psychobiology·E P Zorrilla
May 1, 1997·Neuroscience and Biobehavioral Reviews·L J VanderschurenJ M Van Ree
Dec 22, 1999·The Journal of Clinical Endocrinology and Metabolism·T A Ishunina, D F Swaab
Dec 12, 2001·Nature Neuroscience·D R GrosshansM D Browning
Jan 5, 2002·Journal of Substance Abuse·B F GrantT C Harford
Dec 3, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Isadora F BielskyLarry J Young
Sep 18, 2004·Peptides·Isadora F Bielsky, Larry J Young
Feb 3, 2005·Journal of Anxiety Disorders·Barbara LopezLissette M Saavedra
Mar 31, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul R LeeJames I Koenig
Jun 2, 2006·Alcoholism, Clinical and Experimental Research·Vivian B Faden
Jul 5, 2006·Archives of Pediatrics & Adolescent Medicine·Ralph W HingsonMichael R Winter
Oct 28, 2006·Alcoholism, Clinical and Experimental Research·Cindy L EhlersKirk C Wilhelmsen
Jan 18, 2007·Behavioural Brain Research·Nobuaki EgashiraMichihiro Fujiwara
Feb 20, 2007·Behavior Modification·Norman B SchmidtMeghan E Keough
Jun 2, 2007·Brain Research·Paul R LeeJames I Koenig
Dec 29, 2007·The American Journal of Drug and Alcohol Abuse·Thiago Marques FidalgoDartiu Xavier da Silveira
Jun 10, 2008·Recent Patents on CNS Drug Discovery·Neal G SimonGary A Koppel
Aug 9, 2008·Developmental Review : DR·B J CaseyAdriana Galvan
Oct 3, 2008·Alcoholism, Clinical and Experimental Research·Deborah A DawsonBridget F Grant
Nov 8, 2008·Science·Zoe R Donaldson, Larry J Young
Apr 7, 2009·Physiology & Behavior·Tamara L Doremus-FitzwaterLinda P Spear
Apr 23, 2009·American Journal of Physiology. Endocrinology and Metabolism·Toni R PakRobert J Handa
May 19, 2010·Pharmacology, Biochemistry, and Behavior·Elena I VarlinskayaLinda P Spear
Jan 7, 2011·The Journal of Pharmacology and Experimental Therapeutics·Marvin R DiazBrian A McCool
Jun 17, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael LukasInga D Neumann

❮ Previous
Next ❯

Citations

Nov 6, 2018·Psychopharmacology·Kathryn M HarperGeorge R Breese
Jul 25, 2019·Alcoholism, Clinical and Experimental Research·Fulton T CrewsRyan P Vetreno
Aug 7, 2019·Alcoholism, Clinical and Experimental Research·Kathryn M HarperGeorge R Breese
Apr 19, 2020·Neuropharmacology·Joanna PerisEric G Krause
Jun 9, 2021·Neuroscience and Biobehavioral Reviews·Andrey E Ryabinin, Hannah D Fulenwider

❮ Previous
Next ❯

Methods Mentioned

BETA
antisense nucleotides
electrophoresis

Software Mentioned

BLAST
NIH Image J

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.