PMID: 7543252Jul 1, 1995Paper

Oxytocin as an antidiuretic hormone. I. Concentration dependence of action

The American Journal of Physiology
C L ChouM A Knepper

Abstract

Circulating concentrations of oxytocin increase to 10-40 pM in rats in response to osmotic stimuli, suggesting that oxytocin could play a role in regulation of water balance. The present studies tested whether oxytocin at such concentrations increases osmotic water permeability (Pf) in isolated perfused terminal inner medullary collecting ducts (IMCD). In IMCD segments from Sprague-Dawley rats, 20 pM oxytocin added to the peritubular bath caused a two- to threefold increase in Pf, whereas 200 pM oxytocin increased Pf by five- to sixfold (n = 8, P < 0.01). IMCD from Brattleboro rats, which manifest central diabetes insipidus, exhibited a 2.8-fold increase in Pf in response to 20 pM oxytocin and a 4.7-fold increase in response to 200 pM oxytocin. However, in Brattleboro rats, the response to 20 pM oxytocin was dependent on prior water restriction of the rats. Immunoblotting showed no change in the expression of the aquaporin-CD water channel in Brattleboro rats in response to water restriction. Nevertheless, immunofluorescence studies of inner medullary tissue from Brattleboro rats revealed a marked redistribution of the aquaporin-CD water channels to a predominantly apical and subapical localization in IMCD cells in response to ...Continue Reading

Citations

Apr 6, 2000·American Journal of Physiology. Renal Physiology·L S WeinsteinC A Ecelbarger
May 1, 2004·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·K Jean Cotterman
May 11, 2006·American Journal of Physiology. Renal Physiology·Kay-Pong Yip
Feb 8, 2000·American Journal of Physiology. Renal Physiology·B M ChristensenS Nielsen
Aug 5, 2000·American Journal of Physiology. Renal Physiology·D PromeneurS Nielsen
Nov 28, 2002·American Journal of Physiology. Renal Physiology·Birgitte Mønster ChristensenSøren Nielsen
Jun 10, 2016·American Journal of Physiology. Renal Physiology·Jenny Juan BaiBilly K C Chow
Jul 11, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph D WalchJ Thomas Cunningham
Mar 29, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·B PouzetL Bankir
Jan 5, 2002·Physiological Reviews·Søren NielsenMark A Knepper
Dec 15, 2010·American Journal of Physiology. Renal Physiology·Kay-Pong Yip, James S K Sham
May 25, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J Thomas CunninghamHelmut B Gottlieb

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