Oxytocin attenuates trust as a subset of more general reinforcement learning, with altered reward circuit functional connectivity in males

NeuroImage
Jaime S IdeLilianne R Mujica-Parodi

Abstract

Oxytocin (OT) is an endogenous neuropeptide that, while originally thought to promote trust, has more recently been found to be context-dependent. Here we extend experimental paradigms previously restricted to de novo decision-to-trust, to a more realistic environment in which social relationships evolve in response to iterative feedback over twenty interactions. In a randomized, double blind, placebo-controlled within-subject/crossover experiment of human adult males, we investigated the effects of a single dose of intranasal OT (40 IU) on Bayesian expectation updating and reinforcement learning within a social context, with associated brain circuit dynamics. Subjects participated in a neuroeconomic task (Iterative Trust Game) designed to probe iterative social learning while their brains were scanned using ultra-high field (7T) fMRI. We modeled each subject's behavior using Bayesian updating of belief-states ("willingness to trust") as well as canonical measures of reinforcement learning (learning rate, inverse temperature). Behavioral trajectories were then used as regressors within fMRI activation and connectivity analyses to identify corresponding brain network functionality affected by OT. Behaviorally, OT reduced feedbac...Continue Reading

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Citations

Feb 23, 2019·Frontiers in Neuroscience·Lei XuKeith M Kendrick
Mar 29, 2020·The International Journal of Neuropsychopharmacology·Lilianne R Mujica-Parodi, Helmut H Strey
Nov 16, 2019·Nature Communications·Gabriele BellucciSoyoung Q Park
Nov 7, 2020·Psychopharmacology·Zhijun LiaoSiyang Luo

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