Nov 8, 2018

Oxytocin effects on the resting-state mentalizing brain network

BioRxiv : the Preprint Server for Biology
Haiyan WuQuanying Liu

Abstract

Oxytocin (OT) has effects in both human behavior and in the brain, which is not limited in the specific brain area but also with the potential effect on connectivity with other brain regions. Evidence indicate that the effects of OT on human behavior are multifaceted, such as trust behavior, decrease anxiety, empathy and bonding behavior. Since the vital role of mentalizing in understanding others, here we proposed and tested that whether OT has a general effect on theory of mind brain network which is associated to the effect of related social behavioral and personality traits. Used a randomized, double-blind placebo-controlled group design, we investigated the resting-state functional magnetic resonance imaging after intranasal OT or placebo. The functional connectivity (FC) maps with seed in left temporoparietal junction (lTPJ) and right TPJ showed that OT significantly increased connectivity between rTPJ and default attention network (DAN), while decreased the FC between lTPJ and medial prefrontal network (MPN). With implementing machine learning approach, we further reported satisfactory classification accuracy that Identified altered FCs of TPJ can classify OT and PL group. Moreover, individual empathy trait can modulate ...Continue Reading

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Mentioned in this Paper

Biological Neural Networks
Magnetic Resonance Imaging
Wernicke Aphasia
Facial Colliculus
Brain
Fluorocitrate
Right
Neural Stem Cells
Oxytocin
Multifaceted

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