Oxytocin-enhanced motivational interviewing group therapy for methamphetamine use disorder in men who have sex with men: study protocol for a randomized controlled trial

Trials
Christopher S StaufferJosh D Woolley

Abstract

The prevalence of methamphetamine use disorder (MUD) in the United States has risen dramatically in the past four decades and is concentrated in populations such as men who have sex with men (MSM). Despite the public health consequences of MUD, there are no FDA-approved psychopharmacological treatments. Psychosocial treatment alone has been shown to reduce methamphetamine use, but high attrition rates limit treatment efficacy. Promising findings from animal models of MUD using exogenous oxytocin, a social neuropeptide, have set the stage for translational work. Along with unique anti-addiction effects, oxytocin holds a primary role in enhancing social salience and modulating stress. In humans, oxytocin administration, combined with evidence-based psychosocial interventions, may act synergistically to improve addiction treatment outcomes and improve retention rates in current MUD treatment. We are conducting a randomized, double-blind, placebo-controlled trial of oxytocin-enhanced motivational interviewing group therapy (MIGT). Oxytocin or placebo 40 IU is administered intranasally in conjunction with six, weekly MIGT sessions. We will recruit 50 MSM, initiating treatment for MUD from specialized community health programs in San...Continue Reading

Associated Clinical Trials

Aug 26, 2016·Christopher Stauffer

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Citations

Nov 13, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicholas A EverettJennifer L Cornish
May 26, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicholas A EverettJennifer L Cornish
Feb 6, 2020·The American Journal of Psychiatry·Nora D Volkow
Apr 13, 2021·Current Opinion in Pharmacology·Fabrizio Sanna, Maria Antonietta De Luca

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

Audacity
[UNK] TEAM System
MIGT
MindWare HRV
MindWare
OmniSense
Research Electronic Data Capture ( REDCap )
OE

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