Oxytocin excites nucleus accumbens shell neurons in vivo

Molecular and Cellular Neurosciences
Mahsa MoaddabColin H Brown

Abstract

Oxytocin modulates reward-related behaviors. The nucleus accumbens shell (NAcSh) is a major relay in the brain reward pathway and expresses oxytocin receptors, but the effects of oxytocin on the activity of NAcSh neurons in vivo are unknown. Hence, we used in vivo extracellular recording to show that intracerebroventricular (ICV) oxytocin administration (0.2μg) robustly increased medial NAcSh neuron mean firing rate; this increase was almost exclusively evident in slow-firing neurons and was not associated with any change in firing pattern. To determine whether oxytocin excitation of medial NAcSh neurons is modulated by drugs that impact the brain reward pathway, we next tested the effects of ICV oxytocin following repeated morphine treatment. In morphine-treated rats, ICV oxytocin did not affect the mean firing rate of medial NAcSh neurons. Taken together, these results show that oxytocin excites medial NAcSh neurons but does not do so after repeated morphine. This could be an important factor in oxytocin modulation of reward-related behaviors, such as drug addiction.

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Citations

Dec 26, 2016·Peptides·Richard J Bodnar
Dec 10, 2017·Reviews in the Neurosciences·Mohammed Gamal-Eltrabily, Alfredo Manzano-García
Apr 1, 2018·Journal of Neuroendocrinology·D E Olazábal
Jan 31, 2018·Nature Neuroscience·Morgan M Rogers-CarterJohn P Christianson
Oct 3, 2020·Frontiers in Human Neuroscience·Alan R Harvey
Jan 10, 2021·Communications Biology·Mahsa MoaddabMichael A McDannald
Apr 19, 2020·Neuropharmacology·Joanna PerisEric G Krause
Mar 24, 2021·Current Biology : CB·Mahsa Moaddab, Michael A McDannald
Apr 13, 2021·Current Opinion in Pharmacology·Fabrizio Sanna, Maria Antonietta De Luca

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