PMID: 9178353Mar 26, 1997Paper

Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats: correlation with penile erection and yawning

Regulatory Peptides
M R MelisA Argiolas

Abstract

A dose of oxytocin (50 ng i.c.v.) that induces penile erection and yawning, increased the concentration of NO2- from 0.98 +/- 0.29 to 4.2 +/- 0.79 microM and of NO3- from 5.6 +/- 0.33 to 12.03 +/- 0.99 microM in the dialysate from the paraventricular nucleus of the hypothalamus of male rats, as measured by in vivo microdialysis. NO2- concentration was also increased by [Thr4, Gly7]-oxytocin (100 ng i.c.v. and oxytocin(8) (1 microgram i.c.v.) which also induced penile erection and yawning, but not by oxytocin(1-6) (1 microgram i.c.v.) or oxytocin (7-9) 1 microgram i.c.v.), which were unable to induce these behavioral responses. The oxytocin effect on NO2 concentration, penile erection and yawning was prevented by the oxytocin receptor antagonist. d(CH2)5,Tyr(Me)-Orn8-vasotocin (1 microgram i.e.v.) or by the nitric oxide synthase inhibitor, NG-nitro-1-arginine methyl ester (200 micrograms i.c.v.), but not by the dopamine receptor antagonist, haloperidol (0.5 mg/kg i.p.). The nitric oxide scavenger, hemoglobin (200 micrograms i.c.v.), prevented oxytocin-induced NO2- concentration increase, but was unable to prevent penile erection and yawning. Methylene blue (300 micrograms i.c.v.) an inhibitor of guanylate cyclase, was ineffectiv...Continue Reading

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Citations

Dec 4, 2003·Pharmacology, Biochemistry, and Behavior·Salvatora SuccuAntonio Argiolas
May 4, 2005·Pharmacology & Therapeutics·Noboru TodaTomio Okamura
Jul 16, 2013·Progress in Neurobiology·Antonio Argiolas, Maria Rosaria Melis
Sep 12, 2000·European Journal of Pharmacology·M R MelisA Argiolas
Apr 29, 1998·European Journal of Pharmacology·A Argiolas, M R Melis
Apr 26, 2003·European Journal of Clinical Investigation·P ChioderaV Coiro
Apr 3, 2003·The European Journal of Neuroscience·Maria Rosaria MelisAntonio Argiolas
Feb 5, 2010·The European Journal of Neuroscience·T A BaskervilleA J Douglas
Jun 19, 2010·CNS Neuroscience & Therapeutics·Tracey A Baskerville, Alison J Douglas
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Oct 28, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J LiC Liu
Sep 28, 2005·Expert Opinion on Therapeutic Targets·Yasin TemelVeerle Visser-Vandewalle
Oct 19, 2004·Physiology & Behavior·Antonio Argiolas, Maria Rosaria Melis
Dec 10, 2017·Reviews in the Neurosciences·Mohammed Gamal-Eltrabily, Alfredo Manzano-García
Oct 24, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Agnieszka WsolAgnieszka Cudnoch-Jedrzejewska
May 8, 2004·Journal of Endocrinological Investigation·A AversaG Spera
Nov 18, 2005·The Urologic Clinics of North America·Muammer KendirciWayne J G Hellstrom

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