PMID: 9186274May 1, 1997Paper

Oxytocin-induced changes in single cell K+ currents and smooth muscle contraction of guinea-pig gastric antrum

European Journal of Endocrinology
D B DuridanovaH S Gagov

Abstract

To study the effects of oxytocin on both spontaneous phasic contractions and K+ outward currents (IK) of the so-called 'non-target' smooth muscle cells, physiological concentrations of oxytocin ranging between 10(-12) mol/l and 10(-8) mol/l were applied to smooth muscle preparations and single voltage-clamped cells isolated from the circular layer of the guinea-pig gastric antrum. Oxytocin (10(-12) mol/l to 10(-8) mol/l) suppressed, in a dose-dependent manner, the tetrodotoxin- and atropine-resistant spontaneous phasic contractions and shifted rightward the dose-response curves of 10(-7) mol/l charybdotoxin and 10(-3) mol/l BaCl2. In cells with preloaded intracellular Ca2+ stores, oxytocin (10(-12) mol/l to 10(-9) mol/l) caused a dose-dependent activation of the charybdotoxin-blockable non-inactivating component of IK (IK(sl)) of single voltage-clamped cells, which was accompanied by hyperpolarization of the cell membranes. 8Lys-vasopressin and 8arg-vasopressin failed to mimic the effects of oxytocin on both contraction and K+ currents. Further, the oxytocin-induced activation of IK(sl) was effectively antagonized by 5 x 10(-8) mol/l U-73122 or 5 x 10(-6) mol/l 2-nitro-4-carboxyphenyl N,N-diphenylcarbamate (inhibitors of the ce...Continue Reading

Citations

Oct 1, 2007·Frontiers of Medicine in China·Wenwen ZhangYongmei Zhang
Jun 2, 2009·Journal of Chemical Neuroanatomy·K SemenikenB Dudas
Sep 11, 2007·Burns : Journal of the International Society for Burn Injuries·Sevgin Ozlem IşeriBerrak C Yeğen
Mar 25, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J QinC Liu
Jan 18, 2005·Peptides·Sevgin Ozlem IşeriBerrak C Yeğen
Jun 16, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R WangC Y Liu
Dec 17, 2004·Pharmacological Reviews·Régent LaporteIsmail Laher
Apr 2, 2002·World Journal of Gastroenterology : WJG·Chuan-Yong LiuPaulus S Wang
Jan 1, 2003·World Journal of Gastroenterology : WJG·Dong-Ping XieKe-Jing Liu

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