PMID: 2497489Jan 1, 1989Paper

Oxytocin-induced penile erection and yawning in male rats: effect of neonatal monosodium glutamate and hypophysectomy

Psychopharmacology
A ArgiolasG L Gessa

Abstract

Penile erection and yawning induced by the intracerebroventricular (ICV) injection of oxytocin (10-1000 ng) was studied in hypophysectomized rats and in rats neonatally treated with monosodium glutamate (MSG), a treatment that depletes hypothalamic opiomelanocorticotropin-derived peptides without altering their pituitary and circulating concentration. Oxytocin effect was strongly reduced by hypophysectomy, but not by neonatal MSG. Testosterone replacement (50 micrograms/kg/day for 23 days) partially reversed the effect of hypophysectomy on penile erection, but not on yawning. The present results suggest that oxytocin does not induce penile erection and yawning by releasing an ACTH-derived peptide from hypothalamic opiomelanotropinergic neurons, and that the pituitary gland exerts a permissive role on the expression of the above behavioural responses induced by oxytocin.

References

Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D T KriegerM J Brownstein
Jan 1, 1988·Annals of the New York Academy of Sciences·A ArgiolasG L Gessa
Mar 1, 1985·Hormones and Behavior·R ArlettiA Bertolini
Feb 1, 1987·Pharmacology, Biochemistry, and Behavior·G SerraG L Gessa
Mar 1, 1987·Pharmacology, Biochemistry, and Behavior·A ArgiolasG L Gessa
May 10, 1988·European Journal of Pharmacology·A ArgiolasG Serra
Jan 1, 1987·The Journal of Clinical Endocrinology and Metabolism·M S CarmichaelJ M Davidson
Nov 4, 1986·European Journal of Pharmacology·A ArgiolasG L Gessa
Jan 1, 1985·Pharmacology, Biochemistry, and Behavior·B HolmgrenJ R Eguíbar
Jun 1, 1985·Neuropeptides·R Arletti, A Bertolini
Oct 1, 1985·The Journal of Endocrinology·M D StonehamK Todd
Jun 8, 1971·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·E BergaminiC Pellegrino
Apr 1, 1981·Journal of Endocrinological Investigation·A Bertolini, G L Gessa
Dec 1, 1983·Pharmacology, Biochemistry, and Behavior·G SerraG L Gessa

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Citations

Apr 29, 1998·European Journal of Pharmacology·A Argiolas, M R Melis
May 19, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zhu LiHerbert Y Meltzer
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·A Argiolas, G L Gessa

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