Oxytocin-induced postinhibitory rebound firing facilitates bursting activity in oxytocin neurons

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jean-Marc IsraelStéphane H R Oliet

Abstract

During parturition and lactation, neurosecretory oxytocin (OT) neurons in the hypothalamus achieve pulsatile hormone secretion by coordinated bursts of firing that occur throughout the neuronal population. This activity is partly controlled by somatodendritic release of OT, which facilitates the onset and recurrence of synchronized bursting. To further investigate the cellular mechanisms underlying the control exerted by OT on the activity of its own neurons, we studied the effects of the peptide on membrane potential and synaptic activity in OT neurons in hypothalamic organotypic slice cultures. Bath application of low concentrations of OT (<100 nM) facilitated GABA(A) receptor-mediated inhibitory transmission through a presynaptic mechanism without affecting membrane potential and excitatory glutamatergic synaptic activity. The facilitatory action of OT on GABAergic transmission was dose-dependent, starting at 25 nM and disappearing at concentrations >100 nM. As shown previously, higher concentrations of OT (>500 nM) had the opposite effect, inhibiting GABA(A) receptors via a postsynaptic mechanism. Surprisingly, OT-mediated facilitation of GABAergic transmission promoted action potential firing in 40% of the neurons. Each ac...Continue Reading

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Feb 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stéphane H R OlietJaideep S Bains

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Citations

Nov 3, 2009·The Journal of Reproduction and Development·Kazumasa Honda, Takashi Higuchi
Oct 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicholas D DeLongMichael P Nusbaum
Jul 27, 2014·The Journal of Physiology·Linda A MortonJeffrey G Tasker
Feb 4, 2010·The Journal of Physiology·Ion R PopescuJeffrey G Tasker
Jun 26, 2009·Progress in Neurobiology·Laura LossiAdalberto Merighi
Mar 10, 2010·Journal of Neuroendocrinology·W E ArmstrongR Teruyama
Jan 30, 2014·Journal of Midwifery & Women's Health·Aleeca F BellC Sue Carter
Jul 31, 2014·Journal of Neuroendocrinology·J S LonsteinI D Neumann
May 28, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Erwin H van den BurgOlaf Strauss
Jun 8, 2014·Frontiers in Neuroendocrinology·Richard PietAllan E Herbison
Aug 23, 2008·Progress in Brain Research·S RamatL M Optican
Jun 9, 2017·Nature Reviews. Neuroscience·Michael P NusbaumEve Marder
Feb 13, 2014·Nature Communications·Jean-Marc IsraelPhilippe Ciofi
Dec 7, 2018·Journal of Neuroendocrinology·William E ArmstrongCelia D Sladek
Apr 23, 2019·Physiological Reports·Ion R PopescuJeffrey G Tasker
Nov 8, 2014·Journal of Neurophysiology·Lie WangWilliam E Armstrong

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