Oxytocin modulates behavioral and physiological responses to a stressor in marmoset monkeys

Psychoneuroendocrinology
Jon CavanaughJeffrey A French

Abstract

Social isolation is a major source of stress and can lead to activation of the hypothalamic-pituitary-adrenal (HPA) axis. The presence of a close social partner can reduce the magnitude of the HPA-axis response during a stressor, a phenomenon known as social buffering. The oxytocin (OXT) system has been identified as one candidate for mediating social buffering due to its role in the facilitation of social bonding and the expression of prosocial behavior. The goal of the present study was to determine whether the OXT system contributes to social buffering of HPA-axis activity in response to stressor exposure in marmoset monkeys (Callithrix jacchus). Male and female marmosets experienced a standardized psychogenic stressor with and without their long-term mate under OXT-treatments (Pro(8)-OXT, Leu(8)-OXT, OXT antagonist, and saline); we assessed HPA-axis activity by measuring urinary cortisol across the stressor. We found that blocking, but not augmenting, the OXT system altered patterns of cortisol and proximity behavior in response to a stressor. We demonstrated that (1) the presence of a mate during a stressor significantly attenuated HPA-axis activity in female, but not male, marmosets; (2) male, but not female, marmosets tr...Continue Reading

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Citations

Mar 30, 2016·Frontiers in Neuroendocrinology·Jeffrey A FrenchJon Cavanaugh
Jul 14, 2017·Journal of Sex Research·Jeffrey A FrenchStephanie L Womack
Aug 15, 2018·American Journal of Primatology·Lynea R WitczakKaren L Bales
Feb 14, 2018·Integrative Zoology·Aaryn MustoeJeffrey A French
Feb 21, 2019·Journal of Neuroendocrinology·Tatsushi Onaka, Yuki Takayanagi
Sep 29, 2017·Frontiers in Psychology·Jean-Loup RaultFemke T A Buisman-Pijlman
Feb 11, 2018·American Journal of Primatology·James K RillingEbrahim Haroon
Aug 12, 2017·Frontiers in Endocrinology·Jack H TaylorJeffrey A French
Mar 13, 2018·American Journal of Primatology·Jon CavanaughJeffrey A French
Jun 17, 2020·Royal Society Open Science·Martina StockerJorg J M Massen
Dec 12, 2020·Physiology & Behavior·Juan Pablo DamiánElize van Lier
Apr 19, 2020·Neuropharmacology·Joanna PerisEric G Krause
May 8, 2018·Physiology & Behavior·Christa Finkenwirth, Judith M Burkart
May 4, 2017·Neuroscience and Biobehavioral Reviews·Jenni LeppanenJanet Treasure
Jun 12, 2021·Molecular and Cellular Endocrinology·Mariela Faykoo-MartinezMelissa M Holmes

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