Oxytocin polyuria and polydipsia is blocked by NaCl administration in food-deprived male rats

Journal of Neuroendocrinology
Antonio BernalAmadeo Puerto

Abstract

We examined the effects of NaCl injections on the polydipsia and polyuria induced by subcutaneous oxytocin (OT) administration in food-deprived male rats. During the first 12 h of the treatment day, both food deprivation and OT administration increased urine excretion but reduced water intake, water balance (fluid intake minus urine volume) and body weight. OT treatment enhanced urine excretion and the reduction in water balance and body weight without reducing the water intake of food-deprived animals. Analysis of the physiological effects of OT administration showed increases in urinary sodium concentration, sodium excretion and a reduced plasma sodium concentration. During the second 12 h, OT increased both urine excretion and water intake in food-deprived but not in ad lib.-fed rats. However, hypertonic NaCl administration at the start of this second 12-h period blocked the polyuric and polydipsic responses observed in the OT/deprived group but increased the water intake of the ad lib. groups. After the whole 24-h period, animals treated with OT showed a water balance and body weight change matching those observed in Control animals. Although the recording time period is a critical factor to demonstrate the effect of periph...Continue Reading

References

Aug 1, 1992·Neuroendocrinology·R E BlackburnJ G Verbalis
Mar 1, 1991·Endocrinology·J G VerbalisE M Stricker
Dec 1, 1990·Physiology & Behavior·R ArlettiA Bertolini
Jan 1, 1989·Peptides·R ArlettiA Bertolini
Jun 1, 1968·British Journal of Pharmacology and Chemotherapy·R E Dyball
Jul 1, 1966·The American Journal of Physiology·E M Stricker
Feb 1, 1981·Journal of Comparative and Physiological Psychology·E M Stricker
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·M A HaanwinckelJ Antunes-Rodrigues
Mar 1, 1995·The Journal of Endocrinology·R J WindleM L Forsling
Jan 1, 1996·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·K Uvnäs-MobergM Petersson
Apr 1, 1996·Physiology & Behavior·E Björkstrand, K Uvnäs-Moberg
Jan 8, 1999·Regulatory Peptides·M I Phillips, C Sumners
Oct 31, 2000·Nutrition·E M Stricker, A F Sved
Mar 29, 2001·Physiological Reviews·G Gimpl, F Fahrenholz
Feb 4, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S M McCannJ Antunes-Rodrigues
Aug 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Douglas A FittsRobert L Thunhorst
Dec 1, 1961·The Journal of Physiology·J T FITZSIMONS
Dec 4, 2003·Hormone Research·Theodor H LippertAndreas Pfaff
Aug 23, 2005·Vitamins and Hormones·Gareth LengNancy Sabatier
Mar 14, 2007·Experimental Physiology·Charles W BourqueReza Sharif-Naeini
May 8, 2007·Physiology & Behavior·Edward M Stricker, Myriam L Hoffmann
Jun 15, 2007·Hormones and Behavior·A BernalA Puerto
Sep 1, 2007·Medicine and Science in Sports and Exercise·Alan Kim Johnson

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