Oxytocin, vasopressin, and Williams syndrome: epigenetic effects on abnormal social behavior

Frontiers in Genetics
B W Haas, Alicia K Smith

Abstract

Williams syndrome (WS) is a condition caused by a deletion of ∼26-28 genes on chromosome 7q11.23 often characterized by abnormal social behavior and disrupted oxytocin (OT) and vasopressin (AVP) functioning. The observation that individuals with WS exhibit OT and AVP dysregulation is compelling. There is currently a lack of evidence that any of the genes typically deleted in WS have any direct effect on either OT or AVP. In this perspective article, we present a novel epigenetic model describing how DNA methylation may impact the expression of key genes within the OT and AVP systems, which may ultimately influence the social behavior observed in WS. We draw support from data pooled from a prior empirical research study (Henrichsen et al., 2011), demonstrating that OXTR is overexpressed in WS. These preliminary findings may create new opportunities to target the OT and AVP systems with the specific goal of improving outcomes in WS and other psychiatric conditions.

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Citations

Jul 6, 2016·Frontiers in Neuroscience·Constantina Theofanopoulou
Jun 19, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Shota NishitaniAlicia K Smith
Nov 5, 2020·Autism : the International Journal of Research and Practice·Amy Niego, Antonio Benítez-Burraco
May 14, 2017·Neuroscience and Biobehavioral Reviews·Bernard J Crespi, Tanya L Procyshyn

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