Ozagrel reverses streptozotocin-induced constriction of arterioles in rat retina.

Microvascular Research
Seungjun LeeNorman R Harris

Abstract

Retinal blood flow decreases early in the progression of diabetic retinopathy; however, the mediators and mechanisms responsible for this decrease have yet to be determined. In this study, diabetes was induced by streptozotocin in rats, and retinal blood flow was measured via intravital microscopy 1 or 3 weeks following the induction of hyperglycemia. Additionally, retinal arteriolar diameters and flow were measured prior to and following acute administration of the thromboxane synthase inhibitor ozagrel to investigate the potential role of thromboxane in the observed constriction. Minimal changes in the retinal diameters and flow were observed at 1 week of diabetes; however, at 3 weeks of diabetes, arteriolar constriction and decreases in blood flow were significant. Notably, the constriction occurred only in the arterioles that were in closer proximity to the venules draining the retina. Acute administration of ozagrel reversed the constriction of the closely venule-paired arterioles. In summary, the results suggest that thromboxane mediates localized, venule-dependent arteriolar constriction induced by streptozotocin-induced diabetes in rats.

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Citations

Nov 10, 2012·Investigative Ophthalmology & Visual Science·Travis W HeinLih Kuo
Apr 11, 2013·Investigative Ophthalmology & Visual Science·Wendy LeskovaNorman R Harris
Jul 17, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sergiu-Bogdan Catrina
Mar 24, 2012·Experimental Eye Research·William S WrightNorman R Harris
Jun 11, 2011·Experimental Eye Research·Zhongli WangNorman R Harris
Nov 11, 2008·Experimental Eye Research·William S WrightNorman R Harris
Jul 24, 2015·Journal of Molecular Neuroscience : MN·Agata Grazia D'AmicoVelia D'Agata
Jun 16, 2009·Experimental Eye Research·William S WrightNorman R Harris
Dec 3, 2016·Journal of Molecular Neuroscience : MN·Agata Grazia D'AmicoVelia D'Agata
Apr 20, 2011·Current Eye Research·Amit Singh Yadav, Norman R Harris
Jun 20, 2019·Journal of Diabetes Research·Neda Rajamand EkbergSergiu-Bogdan Catrina
Apr 9, 2019·Biorheology·Norman R HarrisPatsy R Carter

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