Ozone does not react with human erythrocyte membrane lipids

Archives of Biochemistry and Biophysics
J B MuddJ Santrock

Abstract

Ozone was applied to sealed red cell ghost membranes at the rate of 95 nmol/min for periods up to 20 min. Acetylcholine esterase, on the outer face of the membrane, was inhibited up to 20%. Glyceraldehyde-3-phosphate dehydrogenase, on the inner surface of the membrane, was inhibited up to 87%. These differences reflected the inherent susceptibilities of the two enzymes and the presence or absence of the membrane barrier. Analysis of the total lipids of the ozone-treated ghosts showed no significant change in the distribution of lipid classes and no significant change in the fatty acid composition. There was no significant change in the fatty acid composition of the phosphatidylcholine fraction. There was a slight increase in 18:0 and 20:2 + 20:3 in the phosphatidylethanolamine fraction. There was no change in the molecular species distribution of the phosphatidylcholine or the phosphatidylethanolamine fraction. There was no evidence for the formation of the phospholipid ozonolysis product, 1-acyl-2-(9-oxo-nonanyl) derivatives of glyceryl-phosphoryl choline. There was no decline in the amount of cholesterol in the lipids derived from ozone-treated red cell membranes. Treatment of red cell ghost membranes and, by implication, the...Continue Reading

References

Oct 1, 1975·Journal of Biochemistry·M KurodaK Narita
Nov 1, 1992·Toxicology and Applied Pharmacology·J M Samet, M Friedman
Oct 30, 1992·Biochemical and Biophysical Research Communications·W A PryorE Bermúdez
Feb 14, 1992·Science·J V HallS D Colome
Feb 24, 1992·FEBS Letters·C E CrossB Halliwell
Jan 1, 1992·Free Radical Research Communications·C E CrossB Halliwell
Jun 5, 1991·Biochimica Et Biophysica Acta·S A ShelleyJ U Balis
Aug 1, 1989·The American Review of Respiratory Disease·J S TepperG E Hatch
Feb 1, 1988·The American Review of Respiratory Disease·G D LeikaufH E Wey
Nov 1, 1969·Atmospheric Environment·J B MuddT T McManus
Feb 15, 1984·Archives of Biochemistry and Biophysics·K L Knight, J B Mudd
Oct 15, 1982·Archives of Biochemistry and Biophysics·M M Dooley, J B Mudd
Mar 1, 1995·Environmental Health Perspectives·G D LeikaufK E Driscoll
Aug 1, 1995·Archives of Biochemistry and Biophysics·A Van der VlietC E Cross
May 10, 1995·Archives of Biochemistry and Biophysics·R M UppuW A Pryor
Nov 1, 1996·Archives of Biochemistry and Biophysics·J B MuddJ Santrock
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

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Citations

Jun 19, 2004·Mediators of Inflammation·Velio Bocci
Oct 28, 1998·Environmental Health Perspectives·C E CrossB Halliwell
Jan 15, 2005·Free Radical Biology & Medicine·Carol A BallingerEdward M Postlethwait
Apr 5, 2003·Environment International·Jürg Fuhrer, Fitzgerald Booker
May 16, 2012·Free Radical Research·Velio Bocci
Jul 28, 2016·Biochimica Et Biophysica Acta·Philip A Bromberg
Oct 21, 1998·The Journal of General Psychology·F R FerraroJ J Plaud
Jun 25, 1998·The American Journal of Physiology·E M PostlethwaitW A Pryor
Aug 7, 2007·International Journal of Biological Macromolecules·Valter TravagliVelio Bocci

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