Ozone-induced accelerated lung clearance of 99mTc-DTPA aerosol in conscious sheep

Respiration Physiology
W J HornofC E Cross

Abstract

This study was initiated to determine the rate and characteristics of 99mTc-DTPA clearance from the lungs of unanesthetized sheep exposed to varying concentrations of O3 for 4 h in a whole-body exposure chamber. Four sheep exposed to 1 ppm O3 had a monoexponential T50 of 274 +/- 81 min (SD), not significantly different from sham exposures (316 +/- 150); 5 sheep exposed to 2 ppm had a T50 of 234 +/- 101 min, not significantly different from sham exposures (364 +/- 131 min). Five additional unanesthetized sheep exposed to 2 ppm for 4 h via a nasotracheal tube had a T50 of 192 +/- 55 min, significantly different from sham exposures (300 +/- 96 min). The results show that the effect of oxidant pollutants on the permeability of alveolobronchiolar epithelium may be assessed in conscious sheep.

References

Feb 1, 1988·The American Review of Respiratory Disease·S R KleebergerE W Spannhake
Jun 1, 1988·Respiration Physiology·W J HornofC E Cross
Jan 1, 1988·Experimental Lung Research·D K BhallaT T Crocker
Jan 1, 1986·Journal of Toxicology and Environmental Health·G E HatchJ A Graham
Jan 1, 1985·Journal of Toxicology and Environmental Health·W J MautzT T Crocker
Jan 1, 1984·Journal of Toxicology and Environmental Health·D B Menzel
Apr 1, 1983·Journal of Toxicology and Environmental Health·M W SielczakW M Abraham
Jun 1, 1984·Environmental Research·W M AbrahamW Oliver

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Citations

Mar 4, 2008·American Journal of Veterinary Research·Laurel J GershwinRichard F Larson
Dec 1, 1990·Respiration Physiology·E S SchelegleC E Cross

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