Ozone-induced alteration in beta-adrenergic pharmacological modulation of pulmonary macrophages

Toxicology and Applied Pharmacology
T J McGovernR B Schlesinger

Abstract

Ozone is a ubiquitous air pollutant which can affect numerous function s of the respiratory system. However, previous work has not provided any information concerning its ability to modulate pharmacological receptors of pulmonary macrophages. This study examined, using a chemiluminescence assay, the beta-adrenergic modulation of pulmonary macrophages harvested from rabbits exposed for 3 hr/day for 5 days to 0.1, 0.3 or 0.6 ppm ozone (O3) or to 3 hr/day for 20 days to 0.1 or 0.3 ppm. Receptor activity was monitored using release of reactive oxygen species (ROS) following administration to the cells of the beta2-receptor agonist, isoproterenol. An O3-exposure concentration-dependent response was observed for isoproterenol efficacy following 5-day exposures, in that 0.1 ppm O3 induced a significant enhancement of beta-adrenergic inhibition of ROS production, 0.3 ppm ozone produced no significant change from control, and 0.6 ppm decreased inhibition. No significant effects on beta-adrenergic modulation were noted following the 20-day exposures. The results of this study suggest that short-term repeated exposures to O3 are capable of inducing alterations in the pharmacological functioning of pulmonary macrophages, while longer term ...Continue Reading

Citations

Nov 1, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Andres R HenriquezUrmila P Kodavanti

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