Mar 5, 2003

P. aeruginosa quorum-sensing systems and virulence

Current Opinion in Microbiology
Roger S Smith, B H Iglewski

Abstract

Quorum sensing is an important mechanism for the regulation of genes in many Gram-negative and Gram-positive bacteria. In the opportunistic pathogen Pseudomonas aeruginosa, the absence of one or more components of the quorum-sensing system results in a significant reduction in virulence. Recent advances in the past year have demonstrated that the quorum-sensing signal molecule 3O-C(12)-HSL is also a potent stimulator of multiple eukaryotic cells and thus may alter the host response during P. aeruginosa infections. Therefore, via the regulation of multiple factors and the production of 3O-C(12)-HSL, quorum-sensing systems have a significant effect on the virulence of the bacteria and also on how the host responds to P. aeruginosa infections.

Mentioned in this Paper

Gram-Positive Bacteria
Interleukins
Immune Response
Gene Expression Regulation, Bacterial
Pseudomonas aeruginosa (antigen)
Pathogenicity
Pathogenic Organism
Homoserine lactone, (S)-isomer
Pseudomonas aeruginosa
Virulence

About this Paper

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