PMID: 2484861Jan 1, 1989Paper

p-Chloroamphetamine treatment modifies evoked responses to sinusoidal gratings in the pigeon optic tectum

Visual Neuroscience
R AlesciP Bagnoli

Abstract

This study was performed in order to establish whether selective depletion of serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the pigeon optic tectum (TeO) induced by p-chloroamphetamine (p-CA) modified tectal evoked potentials (TEPs). TEPs in response to sinusoidal gratings of different contrast, spatial and temporal frequency were recorded in control pigeons and in pigeons intraperitoneally injected with p-CA (10 mg/kg; two administrations in consecutive days). TEPs of p-CA treated pigeons, as compared to those of control pigeons, were reduced in amplitude as a function of contrast, spatial and temporal frequency. In addition, TEPs of p-CA treated pigeons differed from those recorded in controls in their transfer characteristics of contrast and spatial frequency. In particular, TEPs of p-CA treated pigeons did not saturate at moderate contrast, unlike those of controls. Furthermore, the TEP spatial tuning in p-CA treated pigeons is broader than that in controls; it thus suggests a reduction of spatial-frequency selectivity. These findings indicate that a selective neurotoxin for serotonergic systems, such as p-CA, can serve as a useful denervation tool for the study of the serotonergic function in t...Continue Reading

References

Oct 1, 1976·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·P G Clarke, D Whitteridge
Jan 1, 1975·Brain, Behavior and Evolution·T J Voneida, N K Mello
Aug 18, 1987·Brain Research·G A MarksH P Roffwarg
Jan 1, 1989·Visual Neuroscience·V PorciattiP Bagnoli
Aug 1, 1973·Electroencephalography and Clinical Neurophysiology·P PadmosH Spekreuse
Apr 1, 1967·The Journal of Physiology·A V Juorio, M Vogt
Jan 1, 1984·Experimental Brain Research·N LerescheD Jassik-Gerschenfeld
Oct 26, 1981·Brain Research·P BagnoliM Pellegrino

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Citations

Mar 1, 1987·Documenta Ophthalmologica. Advances in Ophthalmology·V PorciattiG Fontanesi
Jan 1, 1991·Vision Research·V PorciattiF Bramanti

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