PMID: 7543087Feb 1, 1995Paper

P-glycoprotein and cell volume-activated chloride channels

Journal of Bioenergetics and Biomembranes
C F Higgins

Abstract

The multidrug resistance P-glycoprotein (P-gp) is an active drug transporter which can expel hydrophobic compounds from cells. Expression of P-gp has many effects on cells and tissues and the physiological function, or functions, of P-gp are still unclear. Recently, expression of P-gp has been associated with altered activity of chloride channels which play a role in regulating cell volume of response to osmotic shock or nutrient uptake. The nature and physiological role of this association has been a subject of some debate. In this article, mechanisms by which P-gp might influence cell volume-activated chloride currents is discussed, and the potential physiological role of this regulation considered.

References

Jan 1, 1992·Annual Review of Cell Biology·C F Higgins
Mar 19, 1992·Nature·M PaulmichlD Clapham
Dec 12, 1991·Biochimica Et Biophysica Acta·B Sarkadi, J C Parker
May 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·M J BuxtonS B Dudbridge
Apr 1, 1989·Physiological Reviews·E K Hoffmann, L O Simonsen
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T R FlotteB J Carter
Dec 1, 1993·The American Journal of Physiology·W BreuerI Z Cabantchik
Jan 1, 1993·Pflügers Archiv : European journal of physiology·M DíazF V Sepúlveda
Aug 1, 1994·The American Journal of Physiology·D B LuckieJ J Wine
Oct 1, 1994·The Journal of Clinical Investigation·J J ZhangC F Higgins
Aug 11, 1994·Nature·M L AshfordJ P Adelman
Jan 1, 1993·Annual Review of Biochemistry·M M Gottesman, I Pastan
Dec 1, 1993·Pflügers Archiv : European journal of physiology·M A ValverdeF V Sepúlveda
Oct 30, 1998·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·J K HortonL Reuss

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Citations

Jan 1, 1993·Cytotechnology·U A Germann
Sep 1, 1996·Metabolic Brain Disease·H Pasantes-Morales
Oct 1, 1996·Molecular Neurobiology·S Basavappa, J C Ellory
Aug 1, 1996·Pflügers Archiv : European journal of physiology·J P WinpennyM A Gray
Jun 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·U A Germann
Dec 21, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S P HämmerleH Wunderli-Allenspach
Nov 13, 2008·Cytotechnology·U A Germann, T C Chambers
Feb 5, 2002·Annual Review of Physiology·Xinhua Li, Steven A Weinman
Jun 22, 2005·Respiratory Research·Margaretha van der DeenDirkje S Postma
Dec 3, 2014·Biochimica Et Biophysica Acta·Kim S HorgerMichael Mayer
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J W SmitD K Meijer
Mar 15, 2006·Immunological Investigations·Raj K IshriGary M Halliday
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A W WolkoffB F Scharschmidt
Jan 25, 2008·Seminars in Ophthalmology·Corey Westerfeld, Shizuo Mukai
Nov 15, 1996·The Journal of Biological Chemistry·M DongL G Baggetto
Mar 26, 1998·Biochimica Et Biophysica Acta·I C West
Dec 3, 1999·Biochimica Et Biophysica Acta·J Young, I B Holland

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