PMID: 8939727Oct 1, 1996Paper

P-glycoprotein and multidrug resistance

Current Opinion in Genetics & Development
M M GottesmanS V Ambudkar

Abstract

Although the phenomenon of simultaneous resistance to multiple cytotoxic drugs (multidrug resistance) in cancer cells has been discussed for more than two decades, and the human and mouse genes encoding an energy-dependent transporter (the multidrug transporter or P-glycoprotein) responsible for multidrug resistance were cloned 10 years ago, there is still considerable controversy about the mechanism of action of this efflux pump and its true biological function. This review summarizes the current research on the mechanism of action of the multidrug transporter, including the hydrophobic cleaner and altered partitioning models, the possible function of P-glycoprotein as a chloride and/or ATP channel, the role of phosphorylation in its function and fact and speculation about its physiological role.

References

Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S V AmbudkarI Pastan
Jan 1, 1992·Trends in Biochemical Sciences·C F Higgins, M M Gottesman
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R L FineB A Chabner
Nov 17, 1995·The Journal of Biological Chemistry·M TominagaY Okada
Nov 10, 1995·The Journal of Biological Chemistry·I L UrbatschA E Senior
Jul 7, 1995·The Journal of Biological Chemistry·A B Shapiro, V Ling
Feb 1, 1995·Journal of Bioenergetics and Biomembranes·S V Ambudkar
Feb 1, 1995·Journal of Bioenergetics and Biomembranes·U A GermannM M Gottesman
Aug 18, 1995·The Journal of Biological Chemistry·I L UrbatschA E Senior
Nov 1, 1994·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·D J Gruol, S Bourgeois
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E H AbrahamH F Cantiello
Jan 1, 1993·Annual Review of Physiology·J R Riordan
May 28, 1993·International Journal of Cancer. Journal International Du Cancer·J L WeaverA Aszalos
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·A KralliK R Yamamoto
Jan 1, 1993·Annual Review of Biochemistry·M M Gottesman, I Pastan
Nov 1, 1995·Current Opinion in Oncology·H J BroxtermanJ Lankelma
Dec 27, 1995·FEBS Letters·A E SeniorI L Urbatsch
Jan 19, 1996·The Journal of Biological Chemistry·U A GermannM M Gottesman
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·D de GraafI B Roninson
Mar 1, 1996·International Journal of Cancer. Journal International Du Cancer·M D NorrisI B Roninson
Jun 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P Borst, A H Schinkel
Jan 1, 1995·Annual Review of Genetics·M M GottesmanI Pastan
May 1, 1996·The American Journal of Physiology·J L WeaverA Aszalos

❮ Previous
Next ❯

Citations

Feb 7, 2001·Biochemical and Biophysical Research Communications·X Q RenS Akiyama
Jan 1, 1993·Cytotechnology·U A Germann
Jun 8, 2004·Archives of Pharmacal Research·Jong Han LeeJoo Hun Lee
Feb 5, 2005·European Journal of Clinical Pharmacology·Aurel C AllabiJean-Luc Gala
Aug 24, 2011·Cancer Chemotherapy and Pharmacology·Denise Campos-ArroyoJorge Melendez-Zajgla
May 6, 2009·International Journal of Colorectal Disease·Mariusz PanczykMarek Mirowski
Jun 10, 2010·International Journal of Colorectal Disease·Ewa BalcerczakMarek Mirowski
Aug 13, 2009·Breast Cancer Research and Treatment·UNKNOWN MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk
Jan 18, 2006·Journal of Computer-aided Molecular Design·J CartmellD E Leahy
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Dhananjay Pal, Ashim K Mitra
May 28, 2013·International Journal of Hematology·Akihiro Takeshita
Jul 23, 1998·The American Journal of Medicine·E M SchwiebertC M Fuller
Oct 6, 2000·Biochemical Pharmacology·C Marbeuf-GueyeA Garnier-Suillerot
Jul 14, 1998·Molecular and Biochemical Parasitology·J CarltonD Walliker
Dec 21, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S P HämmerleH Wunderli-Allenspach
Sep 23, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E TokunagaK Sugimachi
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C A PlouzekG C Yeh
Feb 15, 2001·Trends in Microbiology·M I Borges-Walmsley, A R Walmsley
Jan 16, 2003·Trends in Microbiology·Kenneth S McKeeganAdrian R Walmsley
Jun 4, 1999·Trends in Microbiology·B P Rosen
Nov 9, 2001·Drug Discovery Today·Lifeng HeSusan Band Horwitz
Aug 9, 2002·Trends in Plant Science·Christian Luschnig
Nov 13, 2008·Cytotechnology·U A Germann, T C Chambers
Nov 13, 2008·Cytotechnology·M G RumsbyJ R Warr
Aug 30, 2008·Nature Medicine·Kimi HonmaTakahiro Ochiya
Dec 12, 2001·British Journal of Pharmacology·M D PerloffD J Greenblatt
May 8, 2002·British Journal of Clinical Pharmacology·Siegfried DrescherMartin F Fromm
Jan 29, 2000·Molecular Microbiology·J Li, B P Rosen
Jul 30, 2011·Molecular & Cellular Proteomics : MCP·Seok-Won HyungDong-Young Noh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

© 2021 Meta ULC. All rights reserved