P-glycoprotein expression in human major and minor salivary glands

Archives of Oral Biology
T UematsuD Kayamoto

Abstract

Sodium pump and carbonic anhydrase activity have been described in the salivary glands. However, it remains to be elucidated whether these energy sources are used for secretion, excretion or both. In addition, the differences in the function of excretion and the role of the excretory duct cells are currently unknown in salivary glands. Expression of P-glycoprotein (P-gp), which is an ATPase-binding efflux pump, was tested in normal major and minor salivary glands from humans. P-gp was distributed on the basolateral membrane of serous acinar cells in the major salivary glands and the minor salivary glands. In particular, it was found to be present on the basolateral membrane and cytoplasm of acinar demilunar cells in the anterior lingual gland. Intense expression was identified in the basolateral membrane of the striated duct cells of the major salivary glands. P-gp was distinctly positive in the basolateral and/or luminal membranes of the initial part and in the luminal membrane of the terminal part of the excretory duct cells of the major salivary glands, whereas it was positive in the luminal membranes of both the initial part and the terminal part of the excretory duct cells of the minor salivary glands. These disparate dist...Continue Reading

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Citations

Oct 26, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vladimir BelostotskyNicholas J A Webb
Apr 15, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Janet HardyBruce Charles
Mar 5, 2003·Archives of Oral Biology·Takashi UematsuKiyofumi Furusawa
Sep 9, 2004·Archives of Oral Biology·Paula SchaiquevichRubio Modesto
Mar 1, 2008·Journal of Veterinary Pharmacology and Therapeutics·A HartmannK Hartmann
Jun 19, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·David J WagnerJoanne Wang
Jan 8, 2019·Journal of Analytical Toxicology·Lina Dorthea BruunGudrun Høiseth
Oct 2, 2019·International Journal of Molecular Sciences·Joanna Lapczuk-RomanskaMarek Drozdzik

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