PMID: 11314336Apr 21, 2001Paper

P-glycoprotein expression in squamous cell carcinoma of the oral and maxillofacial region

The Chinese Journal of Dental Research : the Official Journal of the Scientific Section of the Chinese Stomatological Association (CSA)
Z J XieQ L Wu

Abstract

To investigate the mechanism of drug resistance in oral and maxillofacial carcinoma to chemotherapy. Forty cases of squamous carcinoma in the oral and maxillofacial region were examined for the multidrug resistance gene product P-glycoprotein using a monoclonal antibody, MRK16. P-glycoprotein was detected in 62.5% of all samples. P-glycoprotein expression was related to the chemotherapy and the differentiation of carcinoma. P-glycoprotein expression was higher in the post-chemotherapy group than in the non-chemotherapy group (P < 0.05). Well-differentiated tumors expressed P-glycoprotein more frequently (P < 0.05). P-glycoprotein expression was compared with clinical response to chemotherapy. The accuracy rate of prediction was 75%. P-glycoprotein plays an important role in mechanism of drug resistance of squamous cell carcinoma in the oral and maxillofacial region.

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