p-MAPK1/3 and DUSP6 regulate epididymal cell proliferation and survival in a region-specific manner in mice.

Biology of Reproduction
Bingfang XuBarry T Hinton

Abstract

A fully developed, functional epididymis is important for male fertility. In particular, it is apparent that without the most proximal region, the initial segment (IS), infertility results. Therefore, it is important to understand the development and regulation of this crucial epididymal region. We have previously shown that many functions of the IS are regulated by luminal fluid factors/lumicrine factors from the testis. This study provides evidence that lumicrine factors activated the ERK pathway only in epithelial cells of the IS from Postnatal Day (P) 14 to P19 and sustained this activation into adulthood. The activated ERK pathway promoted cell proliferation and differentiation in the developing IS, although in the adult, its role was switched to maintain cell survival. To understand further the regulation of cell proliferation in the IS, we examined the role of DUSP6, an MAPK1/3 (ERK1/2) preferred phosphatase that is also regulated by lumicrine factors in the IS. Utilizing Dusp6(-/-) mice, our studies, surprisingly, revealed that Dusp6 was a major regulator of cell proliferation in the caput and corpus regions, whereas components of the ERK pathway, together with PTEN and SRC, were the major regulators of cell proliferati...Continue Reading

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Citations

Apr 24, 2012·Asian Journal of Andrology·Ching-Hei YeungTrevor G Cooper
Feb 13, 2016·Nature Communications·Jeremy RoySylvie Breton
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Bingfang XuBarry T Hinton
Feb 1, 2012·Gene Expression Patterns : GEP·Huizhen Wang, T Rajendra Kumar
Mar 6, 2016·Developmental Biology·Bingfang XuBarry T Hinton
Nov 21, 2015·Asian Journal of Andrology·Sylvie BretonBongki Kim
Jun 13, 2015·Journal of Molecular Endocrinology·Fernanda N CavalcantiCatarina S Porto
Dec 18, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xiao-Li XieMei Han
Aug 13, 2013·Mechanisms of Development·Xuguang Nie, Lois J Arend
Dec 29, 2016·Molecular Reproduction and Development·Juan XuShengsong Xie
Jun 28, 2014·Endocrinology·Hyun Jung JunAl Charest
Jun 6, 2020·Science·Tessa Lord, Jon M Oatley
Apr 4, 2020·Ecotoxicology and Environmental Safety·Yoo-Jin ParkMyung-Geol Pang

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Methods Mentioned

BETA
PCR
in vitro transcription
protein assay
Assay
Protein array

Software Mentioned

ImageQuant
Kinetworks
ImagePlus

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