P-selectin binds to bacterial lipopolysaccharide

European Journal of Immunology
R MalhotraM I Bird

Abstract

Multiple organ failure associated with disseminated intravascular coagulation is a frequent complication in septic shock patients. Accumulation of platelets and neutrophils in the organs contributes to the manifestation of lipopolysaccharide (LPS)-induced organ failure. Although a direct interaction between LPS and platelets is well documented, the nature of the surface receptor for LPS on platelets is unknown. In this article we show that P-selectin is a receptor for LPS. The binding of LPS to P-selectin is independent of Ca2+, and is blocked by antibodies to P-selectin, lipid A and fucoidan. Platelets pre-treated with thrombin showed fourfold higher binding of fluorescein isothiocyanate (FITC)-conjugated LPS compared to untreated platelets and the binding of FITC-conjugated LPS to platelets was blocked in the presence of anti-P-selectin antibodies. It is likely that the binding of LPS via P-selectin on activated platelets or epithelium could have a significant role in the pathophysiology of organ failure in septic shock.

References

Jan 1, 1995·Critical Reviews in Immunology·G L SuS C Wang
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Dec 1, 1996·The Biochemical Journal·R MalhotraM I Bird
Feb 10, 1997·Atherosclerosis·A D Blann, G Y Lip

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Citations

Jul 25, 2009·Nature Reviews. Drug Discovery·Beat Ernst, John L Magnani
Sep 28, 2000·Critical Care Medicine·S M Opal
Jul 15, 2003·Clinical Microbiology Reviews·Edwin S Van AmersfoortJohan Kuiper
Nov 23, 2006·Infection and Immunity·Christopher J KuckleburgCharles J Czuprynski
Mar 18, 2009·Journal of Veterinary Pharmacology and Therapeutics·A C BrooksF M Cunningham
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y MokunoY Yoshikai
Jan 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasuhiko YamamotoHiroshi Yamamoto
Aug 30, 2020·International Journal of Molecular Sciences·Kathryn HallyFabrice Cognasse

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