P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans.

Frontiers in Genetics
Peter KochunovJohn Blangero

Abstract

We hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure and cerebral atrophy. We tested this hypothesis by performing genetic correlation analyses for 13 mRNA gene expression measures from P-selectin and 11 other genes located in 1q24 region and three magnetic resonance imaging derived indices of cerebral integrity. The subject pool consisted of 369 (219F; aged 28-85, average = 47.1 ± 12.7 years) normally aging, community-dwelling members of large extended Mexican-American families. Genetic correlation analysis decomposed phenotypic correlation coefficients into genetic and environmental components among 13 leukocyte-based mRNA gene expressions and three whole-brain and regional measurements of cerebral integrity: cortical gray matter thickness, fractional anisotropy of cerebral white matter, and the volume of hyperintensive WM lesions. From the 13 gene expressions, significant phenotypic correlations were only found for the P- and L-selectin expression levels. Increases in P-selectin expression levels tracked with decline in cerebral integrity while the opposite trend was observed for L-selectin expression. The correlations for the P-sel...Continue Reading

Citations

Nov 17, 2015·Annals of Human Genetics·Michelle M ClarkJanet S Sinsheimer
Apr 1, 2014·Neurobiology of Aging·Susan WrightL Elliot Hong
Nov 30, 2018·Human Brain Mapping·Peter KochunovThomas E Nichols
Aug 24, 2017·Obesity·Meghann RyanL Elliot Hong

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Methods Mentioned

BETA
PCR

Software Mentioned

BrainVisa
SOLAR
FSL
Sequential Oligogenic Linkage Analysis Routines ( SOLAR )
tract spatial statistics ( TBSS )

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