PMID: 25762641Mar 13, 2015Paper

P-selectin-mediated platelet adhesion promotes tumor growth

Oncotarget
Cuiling QiLijing Wang

Abstract

Blood platelets foster carcinogenesis. We found that platelets are accumulated in human tumors. P-selectin deficiency and soluble P-selectin abolish platelet deposition within tumors, decreasing secretion of vascular endothelial growth factor and angiogenesis, thereby suppressing tumor growth. Binding of the P-selectin cytoplasmic tail to talin1 triggers the talin1 N-terminal head to interact with the β3 cytoplasmic tail. This activates αIIbβ3 and recruits platelets into tumors. Platelet infiltration into solid tumors occurs through a P-selectin-dependent mechanism.

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Citations

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Aug 8, 2021·International Journal of Molecular Sciences·Chiara AgratiMichele Bibas

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