P-selectin Plasma Levels and Genetic Variant Associated With Diabetic Retinopathy in African Americans

American Journal of Ophthalmology
Alan PenmanLucia Sobrin

Abstract

To report the prevalence and risk factors for retinopathy in African Americans with impaired fasting glucose (IFG) and type 2 diabetes in the Jackson Heart Study and to determine if P-selectin plasma levels are independently associated with retinopathy in this population. Prospective, cross-sectional observational study. setting: Community-based epidemiologic study. Total of 629 patients with type 2 diabetes and 266 participants with impaired fasting glucose. Bilateral, 7-field fundus photographs were scored by masked readers for diabetic retinopathy (DR) level. Covariate data including P-selectin plasma levels and genotypes were collected in a standardized fashion. Association between risk factors, including P-selectin plasma levels and genotypes, and retinopathy. The prevalences of any retinopathy among participants with IFG and type 2 diabetes were 9.4% and 32.4%, respectively. Among those with type 2 diabetes, in multivariate models adjusted for age, sex, and other traditional risk factors, higher P-selectin levels were associated with any DR (odds ratio = 1.11, 95% confidence interval = 1.02-1.21, P = .02) and proliferative DR (odds ratio = 1.23, 95% confidence interval = 1.03-1.46, P = .02). To further investigate the rel...Continue Reading

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Citations

Sep 8, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Parisa KolahdouzMohammad Hasan Sheikhha
May 29, 2016·International Journal of Biological Macromolecules·Yingjie XuDelin Duan
Sep 16, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Evangelia PapavasileiouLucia Sobrin
Apr 24, 2018·Acta Ophthalmologica·Suzanne BroadgateVictor Chong
Oct 20, 2018·Current Diabetes Reviews·Salini Scaria Joy, Khalid Siddiqui
Jun 25, 2021·American Journal of Ophthalmology·Lucia SobrinAyellet V Segrè

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